Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 535254..535740 Replicon chromosome
Accession NZ_CP041994
Organism Streptococcus suis strain INT-01

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag FPT06_RS02590 Protein ID WP_011922754.1
Coordinates 535254..535523 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag FPT06_RS02595 Protein ID WP_002938604.1
Coordinates 535513..535740 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPT06_RS02565 531088..532062 - 975 WP_002937257.1 YvcK family protein -
FPT06_RS02570 532059..532946 - 888 WP_002937261.1 RNase adapter RapZ -
FPT06_RS02575 532968..533345 - 378 WP_013730303.1 RidA family protein -
FPT06_RS02580 533529..534848 - 1320 WP_002937278.1 MATE family efflux transporter -
FPT06_RS02590 535254..535523 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPT06_RS02595 535513..535740 - 228 WP_002938604.1 hypothetical protein Antitoxin
FPT06_RS02605 536012..537358 - 1347 WP_013730302.1 asparagine--tRNA ligase -
FPT06_RS02610 537373..538554 - 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
FPT06_RS02615 538551..539048 - 498 WP_002938611.1 DUF5590 domain-containing protein -
FPT06_RS02620 539351..539800 + 450 WP_002938613.1 MarR family transcriptional regulator -
FPT06_RS02625 539863..540408 + 546 WP_002938614.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T134775 WP_011922754.1 NZ_CP041994:c535523-535254 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T134775 NZ_CP041994:c535523-535254 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT134775 WP_002938604.1 NZ_CP041994:c535740-535513 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT134775 NZ_CP041994:c535740-535513 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References