Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 295321..295807 Replicon chromosome
Accession NZ_CP041994
Organism Streptococcus suis strain INT-01

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag FPT06_RS01470 Protein ID WP_002935012.1
Coordinates 295550..295807 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag FPT06_RS01465 Protein ID WP_002935014.1
Coordinates 295321..295560 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPT06_RS10675 290970..291107 + 138 WP_002935027.1 hypothetical protein -
FPT06_RS01440 291120..291854 + 735 WP_013730364.1 beta-carotene 15,15'-monooxygenase -
FPT06_RS01445 291953..292093 + 141 WP_002935023.1 hypothetical protein -
FPT06_RS01450 292106..292489 + 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
FPT06_RS01455 292506..293258 + 753 WP_002935019.1 ABC transporter ATP-binding protein -
FPT06_RS01460 293259..295229 + 1971 WP_013730363.1 FtsX-like permease family protein -
FPT06_RS01465 295321..295560 + 240 WP_002935014.1 hypothetical protein Antitoxin
FPT06_RS01470 295550..295807 + 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPT06_RS01475 295846..296511 + 666 WP_009909826.1 response regulator transcription factor -
FPT06_RS01480 296508..297449 + 942 WP_002935009.1 sensor histidine kinase -
FPT06_RS01485 297525..299033 + 1509 WP_013730362.1 phosphoglucomutase -
FPT06_RS01490 299103..300173 - 1071 WP_002935006.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T134774 WP_002935012.1 NZ_CP041994:295550-295807 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T134774 NZ_CP041994:295550-295807 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT134774 WP_002935014.1 NZ_CP041994:295321-295560 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT134774 NZ_CP041994:295321-295560 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References