Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-yefM/YoeB-RelB
Location 121217..121740 Replicon chromosome
Accession NZ_CP041987
Organism Lactobacillus sp. PV037

Toxin (Protein)


Gene name Txe Uniprot ID -
Locus tag FP435_RS01125 Protein ID WP_265484617.1
Coordinates 121483..121740 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FP435_RS01120 Protein ID WP_265483928.1
Coordinates 121217..121486 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP435_RS01085 (FP435_01075) 116316..117359 + 1044 WP_265483921.1 dTDP-glucose 4,6-dehydratase -
FP435_RS01090 (FP435_01080) 117359..118243 + 885 WP_265483922.1 glucose-1-phosphate thymidylyltransferase RfbA -
FP435_RS01095 (FP435_01085) 118268..118876 + 609 WP_265483923.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
FP435_RS01100 (FP435_01090) 118893..119879 + 987 WP_265483924.1 dTDP-4-dehydrorhamnose reductase -
FP435_RS01105 (FP435_01095) 120127..120357 + 231 WP_265483926.1 DUF6290 family protein -
FP435_RS01110 (FP435_01105) 120747..120848 + 102 WP_265483927.1 MerR family DNA-binding transcriptional regulator -
FP435_RS01115 (FP435_01110) 120861..120989 + 129 Protein_113 dTDP-4-dehydrorhamnose reductase -
FP435_RS01120 (FP435_01115) 121217..121486 + 270 WP_265483928.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FP435_RS01125 (FP435_01120) 121483..121740 + 258 WP_265484617.1 Txe/YoeB family addiction module toxin Toxin
FP435_RS01130 (FP435_01125) 122036..123298 + 1263 WP_265484618.1 Abi family protein -
FP435_RS01135 (FP435_01130) 123671..124735 + 1065 WP_265483929.1 LysM domain-containing protein -
FP435_RS01140 (FP435_01135) 124754..125218 + 465 WP_265483930.1 hypothetical protein -
FP435_RS01145 (FP435_01140) 125317..125883 + 567 WP_265483931.1 hypothetical protein -
FP435_RS01150 (FP435_01145) 125943..126515 - 573 WP_265483932.1 cation-transporting P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10331.87 Da        Isoelectric Point: 10.0206

>T134773 WP_265484617.1 NZ_CP041987:121483-121740 [Lactobacillus sp. PV037]
IMLSWTSKGWEDYLYWQTRGEKRQIKRINNLIKDVMRNPFEGIGKPEALKDNLTGYWSRRIDAKNRLIYSYENKQVIIFS
CKDHY

Download         Length: 258 bp

>T134773 NZ_CP041987:121483-121740 [Lactobacillus sp. PV037]
ATAATGCTCAGTTGGACAAGTAAGGGATGGGAAGACTATCTTTATTGGCAAACTCGAGGAGAGAAACGTCAGATAAAAAG
AATTAATAATTTAATTAAAGACGTTATGCGTAATCCATTTGAAGGTATTGGCAAGCCTGAGGCCTTAAAAGATAATTTAA
CGGGATATTGGTCTAGAAGAATTGATGCAAAAAATAGACTCATTTATTCTTATGAAAATAAACAAGTAATAATATTTTCT
TGTAAGGATCATTACTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10437.58 Da        Isoelectric Point: 4.3697

>AT134773 WP_265483928.1 NZ_CP041987:121217-121486 [Lactobacillus sp. PV037]
MDAVNYSNFREHLKDYFKQVNDRSEPLIVTNKNPEDNVVILSKNEYDAIVETMEIQANSYLMEKIATGRREVESGKLQNH
DLIDFEDKE

Download         Length: 270 bp

>AT134773 NZ_CP041987:121217-121486 [Lactobacillus sp. PV037]
ATGGATGCTGTAAATTATAGTAATTTTAGAGAACATTTGAAAGACTACTTTAAGCAGGTAAATGATAGAAGTGAACCATT
AATTGTAACGAATAAAAACCCTGAAGATAATGTAGTTATTCTTAGTAAAAATGAATACGATGCGATAGTTGAGACGATGG
AAATTCAAGCAAATAGCTATCTAATGGAAAAAATTGCTACAGGTCGTCGTGAAGTTGAGTCAGGTAAACTCCAAAATCAC
GATTTAATAGATTTTGAGGATAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References