Detailed information of TA system TA134772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-yefM/YoeB-RelB
• Location: 1385090..1385613
• Replicon: chromosome
• Accession: NZ_CP041983
• Organism: Lactobacillus sp. PV012

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: -
• Locus tag: FP433_RS06765
• Protein ID: WP_265484617.1
• Coordinates: 1385090..1385347 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FP433_RS06770
• Protein ID: WP_265483928.1
• Coordinates: 1385344..1385613 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP433_RS06740 (FP433_06660)	1380315..1380887	+	573	WP_265483932.1	cation-transporting P-type ATPase	-
FP433_RS06745 (FP433_06665)	1380947..1381513	-	567	WP_265483931.1	hypothetical protein	-
FP433_RS06750 (FP433_06670)	1381612..1382076	-	465	WP_265483930.1	hypothetical protein	-
FP433_RS06755 (FP433_06675)	1382095..1383159	-	1065	WP_265483929.1	LysM domain-containing protein	-
FP433_RS06760 (FP433_06680)	1383532..1384794	-	1263	WP_265484618.1	Abi family protein	-
FP433_RS06765 (FP433_06685)	1385090..1385347	-	258	WP_265484617.1	Txe/YoeB family addiction module toxin	Toxin
FP433_RS06770 (FP433_06690)	1385344..1385613	-	270	WP_265483928.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FP433_RS06775 (FP433_06695)	1385841..1385969	-	129	Protein_1292	dTDP-4-dehydrorhamnose reductase	-
FP433_RS06780 (FP433_06700)	1385982..1386083	-	102	WP_265483927.1	MerR family DNA-binding transcriptional regulator	-
FP433_RS06785 (FP433_06710)	1386473..1386703	-	231	WP_265483926.1	DUF6290 family protein	-
FP433_RS06790 (FP433_06715)	1386951..1387937	-	987	WP_265483924.1	dTDP-4-dehydrorhamnose reductase	-
FP433_RS06795 (FP433_06720)	1387954..1388562	-	609	WP_265483923.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
FP433_RS06800 (FP433_06725)	1388587..1389471	-	885	WP_265486633.1	glucose-1-phosphate thymidylyltransferase RfbA	-
FP433_RS06805 (FP433_06730)	1389471..1390514	-	1044	WP_265486634.1	dTDP-glucose 4,6-dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10331.87 Da
• Isoelectric Point: 10.0206

>T134772 WP_265484617.1 NZ_CP041983:c1385347-1385090 [Lactobacillus sp. PV012]
IMLSWTSKGWEDYLYWQTRGEKRQIKRINNLIKDVMRNPFEGIGKPEALKDNLTGYWSRRIDAKNRLIYSYENKQVIIFS
CKDHY

Nucleotide

• Length: 258 bp

>T134772 NZ_CP041983:c1385347-1385090 [Lactobacillus sp. PV012]
ATAATGCTCAGTTGGACAAGTAAGGGATGGGAAGACTATCTTTATTGGCAAACTCGAGGAGAGAAACGTCAGATAAAAAG
AATTAATAATTTAATTAAAGACGTTATGCGTAATCCATTTGAAGGTATTGGCAAGCCTGAGGCCTTAAAAGATAATTTAA
CGGGATATTGGTCTAGAAGAATTGATGCAAAAAATAGACTCATTTATTCTTATGAAAATAAACAAGTAATAATATTTTCT
TGTAAGGATCATTACTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10437.58 Da
• Isoelectric Point: 4.3697

>AT134772 WP_265483928.1 NZ_CP041983:c1385613-1385344 [Lactobacillus sp. PV012]
MDAVNYSNFREHLKDYFKQVNDRSEPLIVTNKNPEDNVVILSKNEYDAIVETMEIQANSYLMEKIATGRREVESGKLQNH
DLIDFEDKE

Nucleotide

• Length: 270 bp

>AT134772 NZ_CP041983:c1385613-1385344 [Lactobacillus sp. PV012]
ATGGATGCTGTAAATTATAGTAATTTTAGAGAACATTTGAAAGACTACTTTAAGCAGGTAAATGATAGAAGTGAACCATT
AATTGTAACGAATAAAAACCCTGAAGATAATGTAGTTATTCTTAGTAAAAATGAATACGATGCGATAGTTGAGACGATGG
AAATTCAAGCAAATAGCTATCTAATGGAAAAAATTGCTACAGGTCGTCGTGAAGTTGAGTCAGGTAAACTCCAAAATCAC
GATTTAATAGATTTTGAGGATAAGGAATAA