Detailed information of TA system TA134771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 508465..508988
• Replicon: chromosome
• Accession: NZ_CP041982
• Organism: Lactobacillus sp. PV034

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FP432_RS02570
• Protein ID: WP_265489584.1
• Coordinates: 508465..508650 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FP432_RS02575
• Protein ID: WP_265489300.1
• Coordinates: 508722..508988 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP432_RS02530 (FP432_02525)	503550..504188	-	639	WP_265489292.1	SDR family oxidoreductase	-
FP432_RS02535	504330..504464	+	135	WP_265489293.1	SPJ_0845 family protein	-
FP432_RS02540 (FP432_02530)	504717..505154	+	438	WP_265489294.1	hypothetical protein	-
FP432_RS02545 (FP432_02535)	505306..506034	-	729	WP_265489295.1	Rib/alpha-like domain-containing protein	-
FP432_RS02550 (FP432_02540)	506145..506417	-	273	WP_265489296.1	hypothetical protein	-
FP432_RS02555 (FP432_02545)	506417..506821	-	405	WP_265489297.1	hypothetical protein	-
FP432_RS02560 (FP432_02550)	506897..507280	-	384	WP_265489298.1	DUF1828 domain-containing protein	-
FP432_RS02565 (FP432_02555)	507422..508288	-	867	WP_265489299.1	aldo/keto reductase	-
FP432_RS02570 (FP432_02560)	508465..508650	-	186	WP_265489584.1	Txe/YoeB family addiction module toxin	Toxin
FP432_RS02575 (FP432_02565)	508722..508988	-	267	WP_265489300.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FP432_RS02580 (FP432_02570)	509343..509480	-	138	Protein_471	MerR family transcriptional regulator	-
FP432_RS02585 (FP432_02575)	509546..510028	-	483	WP_265489301.1	hypothetical protein	-
FP432_RS02590 (FP432_02580)	510033..510983	-	951	WP_265489302.1	hypothetical protein	-
FP432_RS02595 (FP432_02585)	511353..512012	-	660	WP_265489303.1	helix-turn-helix transcriptional regulator	-
FP432_RS02600	512874..513066	+	193	Protein_475	ISL3 family transposase	-
FP432_RS02605 (FP432_02590)	513097..513828	-	732	WP_265489304.1	DNA/RNA non-specific endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-61)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7342.60 Da
• Isoelectric Point: 10.2703

>T134771 WP_265489584.1 NZ_CP041982:c508650-508465 [Lactobacillus sp. PV034]
IKRINKLIKDVMRIPFEGIGKPEALRDNLTGYWSRRIDAKNRLIYSYENKQIIIFSCKDHY

Nucleotide

• Length: 186 bp

>T134771 NZ_CP041982:c508650-508465 [Lactobacillus sp. PV034]
ATTAAAAGAATTAATAAATTAATTAAAGACGTTATGCGAATCCCATTCGAAGGTATTGGTAAGCCCGAGGCTCTAAGAGA
TAATTTAACAGGTTATTGGTCCCGAAGAATTGATGCCAAAAATAGACTGATCTATTCTTATGAAAATAAACAGATAATAA
TTTTTTCTTGTAAAGATCACTATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10202.40 Da
• Isoelectric Point: 4.3828

>AT134771 WP_265489300.1 NZ_CP041982:c508988-508722 [Lactobacillus sp. PV034]
MDAVNYSNFREHLKDYFKQVNDRSEPLIVTNKQPEDNVVILSKDEYDAMIETMKIQSNDYLMEKIAAGHREVNAAKLQSL
DLIDPDNN

Nucleotide

• Length: 267 bp

>AT134771 NZ_CP041982:c508988-508722 [Lactobacillus sp. PV034]
ATGGATGCCGTAAATTATAGTAATTTTAGAGAACATCTAAAAGATTACTTTAAGCAAGTAAATGATAGAAGTGAACCCTT
AATTGTTACAAACAAACAACCTGAAGATAATGTAGTGATACTAAGTAAAGATGAATATGATGCAATGATTGAAACGATGA
AAATTCAGTCAAATGACTATTTAATGGAAAAAATTGCTGCAGGACATCGTGAGGTAAATGCAGCCAAATTGCAAAGTCTT
GACTTAATAGATCCGGATAATAATTAA