Detailed information of TA system TA134770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 78119..78644
• Replicon: plasmid unnamed1
• Accession: NZ_CP041974
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP 16207

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FPL16_RS00475
• Protein ID: WP_001159863.1
• Coordinates: 78339..78644 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FPL16_RS00470
• Protein ID: WP_000813641.1
• Coordinates: 78119..78337 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPL16_RS00445	73406..73787	+	382	Protein_88	YgiW/YdeI family stress tolerance OB fold protein	-
FPL16_RS00450	73956..74400	+	445	Protein_89	site-specific integrase	-
FPL16_RS00455	74659..75648	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
FPL16_RS00460	76142..76438	-	297	WP_001687482.1	hypothetical protein	-
FPL16_RS00465	76922..77443	-	522	WP_010999942.1	hypothetical protein	-
FPL16_RS00470	78119..78337	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FPL16_RS00475	78339..78644	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FPL16_RS00480	78646..78936	+	291	WP_001266176.1	hypothetical protein	-
FPL16_RS00485	78933..79454	+	522	WP_000198608.1	hypothetical protein	-
FPL16_RS00490	79489..80271	+	783	WP_000082169.1	site-specific integrase	-
FPL16_RS00495	80280..80993	+	714	Protein_98	EAL domain-containing protein	-
FPL16_RS00500	80997..81506	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FPL16_RS00505	81500..81985	+	486	WP_000905606.1	membrane protein	-
FPL16_RS00510	82262..82549	-	288	WP_071530243.1	hypothetical protein	-
FPL16_RS00515	82705..83265	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..113858	113858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T134770 WP_001159863.1 NZ_CP041974:78339-78644 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T134770 NZ_CP041974:78339-78644 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT134770 WP_000813641.1 NZ_CP041974:78119-78337 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT134770 NZ_CP041974:78119-78337 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6