Detailed information of TA system TA134768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 51044..51569
• Replicon: plasmid unnamed
• Accession: NZ_CP041972
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain NCCP 16206

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FPL15_RS00325
• Protein ID: WP_001159863.1
• Coordinates: 51264..51569 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FPL15_RS00320
• Protein ID: WP_000813641.1
• Coordinates: 51044..51262 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPL15_RS00290	46658..47044	+	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
FPL15_RS00295	47097..47258	+	162	WP_015059604.1	hypothetical protein	-
FPL15_RS00300	47585..48574	-	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
FPL15_RS00305	49068..49363	-	296	Protein_61	cytoplasmic protein	-
FPL15_RS23195	49375..49803	+	429	Protein_62	hypothetical protein	-
FPL15_RS00315	49847..50368	-	522	WP_077681952.1	hypothetical protein	-
FPL15_RS00320	51044..51262	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FPL15_RS00325	51264..51569	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FPL15_RS00330	51571..51861	+	291	WP_001266176.1	hypothetical protein	-
FPL15_RS00335	51858..52379	+	522	WP_000198608.1	hypothetical protein	-
FPL15_RS00340	52414..53196	+	783	WP_000082169.1	site-specific integrase	-
FPL15_RS00345	53205..53918	+	714	WP_000545756.1	EAL domain-containing protein	-
FPL15_RS00350	53922..54431	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FPL15_RS00355	54425..54910	+	486	WP_000905606.1	membrane protein	-
FPL15_RS00360	55187..55474	-	288	WP_071530243.1	hypothetical protein	-
FPL15_RS00365	55630..56190	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83299	83299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T134768 WP_001159863.1 NZ_CP041972:51264-51569 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T134768 NZ_CP041972:51264-51569 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT134768 WP_000813641.1 NZ_CP041972:51044-51262 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT134768 NZ_CP041972:51044-51262 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6