Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4462876..4463511 Replicon chromosome
Accession NZ_CP041969
Organism Cohnella sp. KS 22

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FPL14_RS20565 Protein ID WP_182299522.1
Coordinates 4463161..4463511 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FPL14_RS20560 Protein ID WP_182299521.1
Coordinates 4462876..4463157 (+) Length 94 a.a.

Genomic Context

FPL14_RS20540FPL14_RS20550FPL14_RS20555FPL14_RS20560FPL14_RS20565FPL14_RS20570FPL14_RS20575FPL14_RS20580FPL14_RS20545
Location: 4458946..4459410 (465 bp)
Type: Others
Protein ID: WP_182299518.1
Location: 4460215..4461353 (1139 bp)
Type: Others
Protein ID: Protein_4030
Location: 4461504..4462688 (1185 bp)
Type: Others
Protein ID: WP_182299520.1
Location: 4462876..4463157 (282 bp)
Type: Antitoxin
Protein ID: WP_182299521.1
Location: 4463161..4463511 (351 bp)
Type: Toxin
Protein ID: WP_182299522.1
Location: 4463647..4464881 (1235 bp)
Type: Others
Protein ID: Protein_4034
Location: 4465031..4467211 (2181 bp)
Type: Others
Protein ID: WP_182299523.1
Location: 4467334..4467816 (483 bp)
Type: Others
Protein ID: WP_182299524.1
Location: 4459466..4460005 (540 bp)
Type: Others
Protein ID: WP_182299519.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FPL14_RS205404458946..4459410+465WP_182299518.1DUF523 domain-containing protein-
FPL14_RS205454459466..4460005-540WP_182299519.1DUF1697 domain-containing protein-
FPL14_RS205504460215..4461353+1139Protein_4030DUF4367 domain-containing protein-
FPL14_RS205554461504..4462688+1185WP_182299520.1alanine racemase-
FPL14_RS205604462876..4463157+282WP_182299521.1ribbon-helix-helix protein, CopG familyAntitoxin
FPL14_RS205654463161..4463511+351WP_182299522.1type II toxin-antitoxin system PemK/MazF family toxinToxin
FPL14_RS205704463647..4464881+1235Protein_4034aminopeptidase-
FPL14_RS205754465031..4467211+2181WP_182299523.1RNA-binding transcriptional accessory protein-
FPL14_RS205804467334..4467816+483WP_182299524.1Rrf2 family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12919.94 Da        Isoelectric Point: 5.6439

>T134765 WP_182299522.1 NZ_CP041969:4463161-4463511 [Cohnella sp. KS 22]
MIVKRGDVFYADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIEAKTHGMERDSVILLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Download         Length: 351 bp

>T134765 NZ_CP041969:4463161-4463511 [Cohnella sp. KS 22]
TTGATTGTCAAACGCGGGGATGTTTTCTATGCGGATTTGTCGCCGGTCGTCGGTTCGGAGCAGGGCGGAGTGCGCCCGGT
TCTGATTATCCAGAACGATATCGGCAACCGATTCAGTCCGACGGTCATCGTAGCGGCCATAACGGCGCAAATCCAGAAAG
CGAAGTTGCCAACCCACGTCGAAATCGAAGCGAAAACTCATGGCATGGAGCGGGATTCGGTTATCCTGCTGGAACAAATC
CGGACGATCGACAAACAGCGGTTGACGGACAAAATTACGCATTTGGACGATGAAACGATGCGCAAAGTGGATGAAGCTTT
GCAGATCAGCGTAGGTTTAATCGATTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10780.51 Da        Isoelectric Point: 9.6917

>AT134765 WP_182299521.1 NZ_CP041969:4462876-4463157 [Cohnella sp. KS 22]
VANLHNTKRIMISLPDHLLREVDFVVAKENTNRSEIIRQAMKHYLVDRKKRLIRDAMQRGYLEMAKINLHMASEAFHAEE
DAENILGRLVSGV

Download         Length: 282 bp

>AT134765 NZ_CP041969:4462876-4463157 [Cohnella sp. KS 22]
GTGGCCAATTTACACAATACGAAACGCATTATGATCAGTCTTCCGGATCATTTGCTGCGCGAAGTCGATTTCGTCGTCGC
CAAGGAAAATACGAATCGCAGCGAGATTATTCGCCAGGCCATGAAGCATTACCTGGTGGATCGCAAGAAGCGGTTAATTC
GCGACGCGATGCAGCGCGGGTATTTGGAAATGGCTAAAATCAATCTGCATATGGCCTCTGAAGCGTTTCACGCCGAAGAG
GATGCGGAAAACATACTCGGTCGCCTTGTGAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References