Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4462876..4463511 Replicon chromosome
Accession NZ_CP041969
Organism Cohnella sp. KS 22

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FPL14_RS20565 Protein ID WP_182299522.1
Coordinates 4463161..4463511 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FPL14_RS20560 Protein ID WP_182299521.1
Coordinates 4462876..4463157 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPL14_RS20540 4458946..4459410 + 465 WP_182299518.1 DUF523 domain-containing protein -
FPL14_RS20545 4459466..4460005 - 540 WP_182299519.1 DUF1697 domain-containing protein -
FPL14_RS20550 4460215..4461353 + 1139 Protein_4030 DUF4367 domain-containing protein -
FPL14_RS20555 4461504..4462688 + 1185 WP_182299520.1 alanine racemase -
FPL14_RS20560 4462876..4463157 + 282 WP_182299521.1 ribbon-helix-helix protein, CopG family Antitoxin
FPL14_RS20565 4463161..4463511 + 351 WP_182299522.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPL14_RS20570 4463647..4464881 + 1235 Protein_4034 aminopeptidase -
FPL14_RS20575 4465031..4467211 + 2181 WP_182299523.1 RNA-binding transcriptional accessory protein -
FPL14_RS20580 4467334..4467816 + 483 WP_182299524.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12919.94 Da        Isoelectric Point: 5.6439

>T134765 WP_182299522.1 NZ_CP041969:4463161-4463511 [Cohnella sp. KS 22]
MIVKRGDVFYADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIEAKTHGMERDSVILLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Download         Length: 351 bp

>T134765 NZ_CP041969:4463161-4463511 [Cohnella sp. KS 22]
TTGATTGTCAAACGCGGGGATGTTTTCTATGCGGATTTGTCGCCGGTCGTCGGTTCGGAGCAGGGCGGAGTGCGCCCGGT
TCTGATTATCCAGAACGATATCGGCAACCGATTCAGTCCGACGGTCATCGTAGCGGCCATAACGGCGCAAATCCAGAAAG
CGAAGTTGCCAACCCACGTCGAAATCGAAGCGAAAACTCATGGCATGGAGCGGGATTCGGTTATCCTGCTGGAACAAATC
CGGACGATCGACAAACAGCGGTTGACGGACAAAATTACGCATTTGGACGATGAAACGATGCGCAAAGTGGATGAAGCTTT
GCAGATCAGCGTAGGTTTAATCGATTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10780.51 Da        Isoelectric Point: 9.6917

>AT134765 WP_182299521.1 NZ_CP041969:4462876-4463157 [Cohnella sp. KS 22]
VANLHNTKRIMISLPDHLLREVDFVVAKENTNRSEIIRQAMKHYLVDRKKRLIRDAMQRGYLEMAKINLHMASEAFHAEE
DAENILGRLVSGV

Download         Length: 282 bp

>AT134765 NZ_CP041969:4462876-4463157 [Cohnella sp. KS 22]
GTGGCCAATTTACACAATACGAAACGCATTATGATCAGTCTTCCGGATCATTTGCTGCGCGAAGTCGATTTCGTCGTCGC
CAAGGAAAATACGAATCGCAGCGAGATTATTCGCCAGGCCATGAAGCATTACCTGGTGGATCGCAAGAAGCGGTTAATTC
GCGACGCGATGCAGCGCGGGTATTTGGAAATGGCTAAAATCAATCTGCATATGGCCTCTGAAGCGTTTCACGCCGAAGAG
GATGCGGAAAACATACTCGGTCGCCTTGTGAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References