Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1024806..1026238 Replicon chromosome
Accession NZ_CP041968
Organism Streptococcus sp. KS 6

Toxin (Protein)


Gene name abiEi Uniprot ID A0A7L8W7V8
Locus tag FPL13_RS05045 Protein ID WP_049512028.1
Coordinates 1025393..1026238 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A7L8WAJ2
Locus tag FPL13_RS05040 Protein ID WP_049512029.1
Coordinates 1024806..1025396 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPL13_RS05040 1024806..1025396 + 591 WP_049512029.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
FPL13_RS05045 1025393..1026238 + 846 WP_049512028.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FPL13_RS05050 1026335..1029121 - 2787 WP_057489713.1 CHAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-259)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-51)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32585.02 Da        Isoelectric Point: 5.1971

>T134764 WP_049512028.1 NZ_CP041968:1025393-1026238 [Streptococcus sp. KS 6]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEAILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTADIDFLFHKQTLSEE
NIQQQLEEILTESKDGIQFSIQSITAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPYPATYDYKAIFDDDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKDDIDFSQLKIACERTFSYRETELDFNKIIELLERFKSDS
IQQQQWQNYSKKYSYTKDILFTDILNEIISLLIALNSNHNV

Download         Length: 846 bp

>T134764 NZ_CP041968:1025393-1026238 [Streptococcus sp. KS 6]
ATGAATAAAGCAAAATTAACAGCACTCTGCCATAAAATATCGAAGAATACTGGATTAACTTTTAATTCCGTCATGACCTA
TTACTTTCTTGAAGCTATTCTGAAAAAATTAAGTCAGAGTTCTTATTCGAATCACTATATTTTTAAAGGTGGGTTCCTAC
TTTCAAACGTCATTGGGGTCGAATCTCGTAGTACGGCGGATATTGACTTCCTGTTTCATAAACAAACTTTATCAGAAGAA
AATATTCAACAACAGCTTGAAGAAATTTTAACTGAATCGAAAGATGGTATTCAATTTTCAATTCAATCCATAACAGCTAT
TAAGGAAAGCGATGATTATGGTGGTTACCGAGCAACCATTTTATGTCAACTCGAAAATATTAAACAAATTATCCATTTAG
ATATTGCGACTGGAGACATTGTCACACCTTACCCTGCTACCTATGACTACAAAGCCATTTTTGATGATGACAATTTTCCA
ATCATTGCTTATACGATTGAAACAATCTTAGCTGAAAAACTCCAAACCATTTATTCACGAAATTTCTTGAACAGTCGCAG
CAAAGATTTTTACGATGTCTATATCCTTTCAAAGCTAAAGAAAGATGACATTGATTTTTCACAATTAAAAATTGCTTGTG
AAAGAACCTTTTCCTATCGTGAAACTGAACTCGATTTCAATAAAATCATTGAACTACTGGAGAGATTCAAATCTGACTCT
ATTCAACAGCAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGACATTCTATTCACAGATATACTTAATGA
GATTATCAGCCTCTTGATAGCTCTCAATTCTAATCATAACGTTTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23107.52 Da        Isoelectric Point: 7.8604

>AT134764 WP_049512029.1 NZ_CP041968:1024806-1025396 [Streptococcus sp. KS 6]
MSKKELLLEYLDSHNGMITHRDCKKLGIPTIYLTRLENEGVIFRVDKGIYLSSSGDYDEYYFFQYRYPRTVFSHISALYL
QRLTDEIPQYFEVTVPRDYRFRNTPLNLNIHTVSKDIVNLGVTSVKTPMGNTVNVYNFERVLCDFILNRDSIDAELFVKT
LQTYSNFPKKNLSKLYEYAQKLNILDEVKRTLEVLL

Download         Length: 591 bp

>AT134764 NZ_CP041968:1024806-1025396 [Streptococcus sp. KS 6]
ATGTCTAAAAAAGAATTGTTACTTGAGTACTTAGACAGTCACAATGGCATGATTACTCATAGAGATTGTAAAAAATTAGG
TATTCCAACCATTTATCTAACTAGACTAGAAAACGAAGGGGTTATCTTTAGGGTCGATAAAGGAATCTATCTGTCCTCTA
GTGGAGATTATGATGAATACTATTTCTTTCAGTATCGTTACCCCAGAACTGTTTTTTCTCATATCTCTGCTCTTTATCTA
CAGAGACTTACAGATGAAATTCCTCAATATTTTGAAGTAACAGTCCCAAGGGACTACCGTTTTAGGAATACACCATTAAA
TTTAAATATCCACACTGTTTCTAAAGACATTGTCAACCTCGGGGTCACCAGTGTAAAAACTCCAATGGGAAACACCGTTA
ACGTTTATAATTTTGAACGTGTTCTGTGTGATTTTATCCTTAATCGAGATAGCATTGATGCTGAGCTATTTGTTAAAACA
CTTCAAACTTATAGCAACTTCCCTAAAAAAAATCTCTCAAAGCTCTATGAATATGCTCAAAAACTGAATATCTTAGATGA
AGTTAAACGAACCTTGGAGGTACTACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L8W7V8

Antitoxin

Source ID Structure
AlphaFold DB A0A7L8WAJ2

References