Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1007248..1008506 Replicon chromosome
Accession NZ_CP041968
Organism Streptococcus sp. KS 6

Toxin (Protein)


Gene name sezT Uniprot ID A0A7L8W5Y7
Locus tag FPL13_RS04975 Protein ID WP_049512047.1
Coordinates 1007248..1008030 (-) Length 261 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A0P0N8Y9
Locus tag FPL13_RS04980 Protein ID WP_049512045.1
Coordinates 1008030..1008506 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPL13_RS04950 1002383..1004260 - 1878 WP_049512052.1 relaxase/mobilization nuclease domain-containing protein -
FPL13_RS04955 1004247..1004612 - 366 WP_049512050.1 MobC family plasmid mobilization relaxosome protein -
FPL13_RS04960 1004622..1004981 - 360 WP_192208519.1 hypothetical protein -
FPL13_RS04965 1005320..1006462 - 1143 WP_049512049.1 AAA family ATPase -
FPL13_RS04970 1006463..1007251 - 789 WP_049476721.1 hypothetical protein -
FPL13_RS04975 1007248..1008030 - 783 WP_049512047.1 zeta toxin family protein Toxin
FPL13_RS04980 1008030..1008506 - 477 WP_049512045.1 helix-turn-helix domain-containing protein Antitoxin
FPL13_RS04985 1008576..1008863 - 288 WP_049476718.1 hypothetical protein -
FPL13_RS04990 1008908..1009297 - 390 WP_049512043.1 hypothetical protein -
FPL13_RS04995 1009294..1009521 - 228 WP_007520115.1 hypothetical protein -
FPL13_RS05000 1009576..1010664 - 1089 WP_049512042.1 toprim domain-containing protein -
FPL13_RS05005 1010703..1011341 - 639 WP_024052550.1 hypothetical protein -
FPL13_RS05010 1011442..1011726 - 285 WP_192208520.1 hypothetical protein -
FPL13_RS05015 1011742..1012041 - 300 WP_049512039.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 29693.91 Da        Isoelectric Point: 7.9056

>T134763 WP_049512047.1 NZ_CP041968:c1008030-1007248 [Streptococcus sp. KS 6]
MRLEEFSEDEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFTGKMVEHLVDELSIQGYHLLIEGTLRTTEVPRKTTQLLKSRGYQVSLALIATKPELSYLSTLICYEE
VYAVNPSQTRATPKEYHDGIVDHLVENLRELENDKLFDRIQIYQRDRTCIYDSETDEGAAAEVLQKSLFGKWSKVEKEMM
KMGKEKLANLVDKNMIGSKK

Download         Length: 783 bp

>T134763 NZ_CP041968:c1008030-1007248 [Streptococcus sp. KS 6]
ATGAGACTGGAAGAATTTAGTGAGGATGAATTTCAGAAAGCCTTACAGCGAACGATTCGAGCTCTAACTCGTGGAAAGAC
GATTCCAGACCAACCTAAAGCCATCTTGCTTGGTGGTCAAAGTGGAGCAGGAAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAGGGAAATATCGTTATCATTGACGGTGATAGCTATCGTTCTCAGCACCCAAATTACTTAGCTCTGCAAGAA
AAGTATGGTAAAGATAGTGTGGACTACACCAAGGGATTTACAGGAAAAATGGTAGAGCATCTGGTTGATGAACTCAGCAT
ACAAGGCTATCATTTGTTAATTGAAGGAACTTTGAGAACGACGGAAGTCCCAAGAAAAACTACACAGCTATTAAAATCAA
GGGGATACCAAGTCTCGTTAGCCTTGATAGCCACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCTGTTACGAAGAA
GTCTATGCAGTAAATCCAAGCCAAACTAGAGCAACACCTAAAGAGTACCATGATGGTATTGTGGACCATTTGGTTGAGAA
TCTAAGAGAGTTAGAAAACGATAAACTCTTTGACCGCATTCAAATTTATCAAAGAGATAGGACTTGCATTTACGATTCTG
AAACGGATGAGGGGGCAGCAGCAGAAGTTCTTCAAAAATCTCTCTTCGGTAAATGGAGTAAGGTTGAGAAAGAGATGATG
AAGATGGGAAAAGAAAAATTAGCTAACTTAGTAGATAAGAATATGATTGGGAGTAAGAAATGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18288.65 Da        Isoelectric Point: 4.3971

>AT134763 WP_049512045.1 NZ_CP041968:c1008506-1008030 [Streptococcus sp. KS 6]
MIGDNIKSLRRTHDLTQPEFAKIVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLDTVYHRVVA

Download         Length: 477 bp

>AT134763 NZ_CP041968:c1008506-1008030 [Streptococcus sp. KS 6]
ATGATTGGAGATAATATTAAGTCCTTACGCAGAACTCATGATCTAACCCAGCCAGAATTCGCAAAAATTGTTGGGATTTC
ACGCAATAGCTTAAGTCGATATGAAAATGGAACTAGCACGGTTTCAACAGAACTCATCGACCGAATTTGTCAGAAATTTA
ATGTTTCATACGTTGATATTGTAGGGGAGGACAAAATGTTAACACCTGTTGAAGATTACCAACTAACCTTAAAAGTAGAA
GTGATTAAAGAACGTGGAGCAGCCATTCTATCCCAACTCTATCGCTACCAAGATAGTCAGGATATTGCTTTTGATGACGA
AACTAATCCTTGGATTTTGATGAGCGACGATCTGGCTGAATTGATCCATACAAAGATTTACCTTGTTGATACTTTCGATG
AAATAGAGCGTTATAATGGCTATTTAGACGGTATAGAGCGGATGTTAGACACGGTGTATCATCGGGTGGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L8W5Y7

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0N8Y9

References