Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5224457..5225124 Replicon chromosome
Accession NZ_CP041967
Organism Xanthomonas citri pv. glycines strain K2

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag FPL05_RS23885 Protein ID WP_005916679.1
Coordinates 5224708..5225124 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag FPL05_RS23880 Protein ID WP_005916676.1
Coordinates 5224457..5224711 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPL05_RS23855 5220563..5220772 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
FPL05_RS23860 5220955..5222220 + 1266 WP_016849472.1 cardiolipin synthase B -
FPL05_RS23865 5222246..5222773 - 528 WP_005916668.1 hypothetical protein -
FPL05_RS23870 5223012..5223218 + 207 WP_003489327.1 hypothetical protein -
FPL05_RS23875 5223205..5224311 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPL05_RS23880 5224457..5224711 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
FPL05_RS23885 5224708..5225124 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
FPL05_RS23890 5225246..5225518 - 273 WP_124632111.1 hypothetical protein -
FPL05_RS23895 5225531..5225791 - 261 WP_124632112.1 hypothetical protein -
FPL05_RS23900 5226048..5227667 + 1620 WP_016849230.1 enterochelin esterase -
FPL05_RS23905 5227771..5228169 - 399 WP_004429277.1 DUF2384 domain-containing protein -
FPL05_RS23910 5228485..5228916 + 432 WP_016849229.1 hypothetical protein -
FPL05_RS23915 5228945..5229271 - 327 Protein_4401 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T134762 WP_005916679.1 NZ_CP041967:5224708-5225124 [Xanthomonas citri pv. glycines]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T134762 NZ_CP041967:5224708-5225124 [Xanthomonas citri pv. glycines]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAAGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT134762 WP_005916676.1 NZ_CP041967:5224457-5224711 [Xanthomonas citri pv. glycines]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT134762 NZ_CP041967:5224457-5224711 [Xanthomonas citri pv. glycines]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References