Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5160070..5160737 Replicon chromosome
Accession NZ_CP041963
Organism Xanthomonas citri pv. glycines strain 1157

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag FPL03_RS23500 Protein ID WP_005916679.1
Coordinates 5160321..5160737 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag FPL03_RS23495 Protein ID WP_005916676.1
Coordinates 5160070..5160324 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPL03_RS23470 5156176..5156385 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
FPL03_RS23475 5156568..5157833 + 1266 WP_016849472.1 cardiolipin synthase B -
FPL03_RS23480 5157859..5158386 - 528 WP_005916668.1 hypothetical protein -
FPL03_RS23485 5158625..5158831 + 207 WP_003489327.1 hypothetical protein -
FPL03_RS23490 5158818..5159924 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPL03_RS23495 5160070..5160324 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
FPL03_RS23500 5160321..5160737 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
FPL03_RS23505 5160859..5161062 - 204 WP_124944764.1 hypothetical protein -
FPL03_RS23510 5161144..5161404 - 261 WP_124632112.1 hypothetical protein -
FPL03_RS23515 5161661..5163280 + 1620 WP_016849230.1 enterochelin esterase -
FPL03_RS23520 5163384..5163782 - 399 WP_004429277.1 DUF2384 domain-containing protein -
FPL03_RS23525 5164098..5164529 + 432 WP_016849229.1 hypothetical protein -
FPL03_RS23530 5164558..5164884 - 327 Protein_4355 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T134757 WP_005916679.1 NZ_CP041963:5160321-5160737 [Xanthomonas citri pv. glycines]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T134757 NZ_CP041963:5160321-5160737 [Xanthomonas citri pv. glycines]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAAGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT134757 WP_005916676.1 NZ_CP041963:5160070-5160324 [Xanthomonas citri pv. glycines]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT134757 NZ_CP041963:5160070-5160324 [Xanthomonas citri pv. glycines]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References