Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5056663..5057330 Replicon chromosome
Accession NZ_CP041961
Organism Xanthomonas citri pv. glycines strain 1018

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag FPL00_RS22785 Protein ID WP_005916679.1
Coordinates 5056914..5057330 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag FPL00_RS22780 Protein ID WP_005916676.1
Coordinates 5056663..5056917 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPL00_RS22755 5052769..5052978 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
FPL00_RS22760 5053161..5054426 + 1266 WP_016849472.1 cardiolipin synthase B -
FPL00_RS22765 5054452..5054979 - 528 WP_005916668.1 hypothetical protein -
FPL00_RS22770 5055218..5055424 + 207 WP_003489327.1 hypothetical protein -
FPL00_RS22775 5055411..5056517 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPL00_RS22780 5056663..5056917 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
FPL00_RS22785 5056914..5057330 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
FPL00_RS22790 5057452..5057655 - 204 WP_124944764.1 hypothetical protein -
FPL00_RS22795 5057737..5057997 - 261 WP_124632112.1 hypothetical protein -
FPL00_RS22800 5058254..5059873 + 1620 WP_016849230.1 enterochelin esterase -
FPL00_RS22805 5059977..5060375 - 399 WP_004429277.1 DUF2384 domain-containing protein -
FPL00_RS22810 5060691..5061122 + 432 WP_016849229.1 hypothetical protein -
FPL00_RS22815 5061151..5061477 - 327 Protein_4207 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T134753 WP_005916679.1 NZ_CP041961:5056914-5057330 [Xanthomonas citri pv. glycines]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T134753 NZ_CP041961:5056914-5057330 [Xanthomonas citri pv. glycines]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAAGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT134753 WP_005916676.1 NZ_CP041961:5056663-5056917 [Xanthomonas citri pv. glycines]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT134753 NZ_CP041961:5056663-5056917 [Xanthomonas citri pv. glycines]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References