Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4793218..4793734 Replicon chromosome
Accession NZ_CP041946
Organism Klebsiella pneumoniae strain KP2

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FOZ68_RS23480 Protein ID WP_002886902.1
Coordinates 4793218..4793502 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FOZ68_RS23485 Protein ID WP_002886901.1
Coordinates 4793492..4793734 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ68_RS23460 4788634..4788942 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
FOZ68_RS28790 4789027..4789200 + 174 WP_032410138.1 hypothetical protein -
FOZ68_RS23465 4789203..4789946 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
FOZ68_RS23470 4790303..4792441 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FOZ68_RS23475 4792750..4793214 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FOZ68_RS23480 4793218..4793502 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOZ68_RS23485 4793492..4793734 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOZ68_RS23490 4793812..4795722 - 1911 WP_009486549.1 BglG family transcription antiterminator -
FOZ68_RS23495 4795745..4796899 - 1155 WP_023302389.1 lactonase family protein -
FOZ68_RS23500 4796966..4797706 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T134713 WP_002886902.1 NZ_CP041946:c4793502-4793218 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T134713 NZ_CP041946:c4793502-4793218 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT134713 WP_002886901.1 NZ_CP041946:c4793734-4793492 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT134713 NZ_CP041946:c4793734-4793492 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References