Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 583364..583980 Replicon chromosome
Accession NZ_CP041932
Organism Thermococcus aciditolerans strain SY113

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPV09_RS03170 Protein ID WP_148882354.1
Coordinates 583579..583980 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FPV09_RS03165 Protein ID WP_148882353.1
Coordinates 583364..583591 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV09_RS03145 (FPV09_03145) 578588..579589 - 1002 WP_148882350.1 2-hydroxyacid dehydrogenase -
FPV09_RS03150 (FPV09_03150) 579715..581163 + 1449 WP_148883651.1 proline--tRNA ligase -
FPV09_RS03155 (FPV09_03155) 581217..581618 - 402 WP_148882351.1 pyrolysin -
FPV09_RS03160 (FPV09_03160) 581710..583323 + 1614 WP_148882352.1 carbamoyltransferase -
FPV09_RS03165 (FPV09_03165) 583364..583591 + 228 WP_148882353.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FPV09_RS03170 (FPV09_03170) 583579..583980 + 402 WP_148882354.1 PIN domain-containing protein Toxin
FPV09_RS03175 (FPV09_03175) 584127..585296 + 1170 WP_139681694.1 pyridoxal phosphate-dependent aminotransferase -
FPV09_RS03180 (FPV09_03180) 585300..585956 - 657 WP_148882355.1 metallophosphoesterase -
FPV09_RS03185 (FPV09_03185) 586006..586554 - 549 WP_148882356.1 adenylate kinase family protein -
FPV09_RS03190 (FPV09_03190) 586685..586906 + 222 WP_139681692.1 hypothetical protein -
FPV09_RS03195 (FPV09_03195) 586974..588191 - 1218 WP_148882357.1 methionine adenosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(5-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15364.58 Da        Isoelectric Point: 4.6921

>T134688 WP_148882354.1 NZ_CP041932:583579-583980 [Thermococcus aciditolerans]
MHGVIDTNVIIYDTFEDSEFHSEAEDVLESLDTWYIPAIVLQEFVWFFKNNGFSAEETWEVLKGYLDDPRFRGLKDGPET
VKMAFELLKSEKISLSRFNDAMILVHAIDKGVLVTFDSKFRKLARRTGVKVLP

Download         Length: 402 bp

>T134688 NZ_CP041932:583579-583980 [Thermococcus aciditolerans]
ATGCATGGAGTGATAGACACGAACGTCATCATCTACGACACCTTCGAGGACTCCGAGTTTCACAGCGAGGCAGAAGATGT
CCTGGAGTCCCTCGATACGTGGTATATACCGGCGATAGTCCTTCAGGAGTTCGTCTGGTTCTTCAAGAACAACGGATTTT
CCGCTGAGGAGACGTGGGAAGTTCTGAAGGGCTACCTCGATGACCCGAGGTTCAGGGGGCTTAAGGACGGCCCCGAAACC
GTGAAGATGGCCTTTGAGCTTCTGAAATCTGAGAAGATTTCACTCTCTCGCTTCAACGACGCGATGATTTTAGTCCACGC
CATTGATAAAGGCGTTCTGGTAACGTTCGACTCCAAGTTCAGGAAGTTGGCCAGGAGAACGGGTGTCAAAGTCCTCCCGT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8757.39 Da        Isoelectric Point: 10.3979

>AT134688 WP_148882353.1 NZ_CP041932:583364-583591 [Thermococcus aciditolerans]
MSITKVTRNYQITIPAEIRKALGIREGELLEVHIEGDKIVLKRLERKRKRLRLGKRLSPEEIERAIEGGMKECME

Download         Length: 228 bp

>AT134688 NZ_CP041932:583364-583591 [Thermococcus aciditolerans]
ATGAGCATTACCAAAGTAACCCGCAACTATCAGATAACGATTCCAGCGGAGATTAGAAAGGCGCTCGGGATAAGGGAGGG
GGAGCTCCTCGAAGTTCACATTGAGGGTGACAAGATAGTGCTCAAAAGGCTGGAGAGGAAGAGAAAGAGGCTCAGACTTG
GAAAAAGGCTTTCTCCGGAGGAAATCGAGAGGGCCATCGAGGGGGGCATGAAGGAATGCATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References