Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 152889..153652 Replicon plasmid pSECR18-2374A
Accession NZ_CP041928
Organism Klebsiella pneumoniae strain 18-2374

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FOM15_RS27020 Protein ID WP_148053329.1
Coordinates 152889..153398 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag FOM15_RS27025 Protein ID WP_014386183.1
Coordinates 153386..153652 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOM15_RS26995 148284..148724 + 441 WP_014386179.1 IS66 family insertion sequence hypothetical protein -
FOM15_RS27000 148721..149071 + 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
FOM15_RS27005 149102..150694 + 1593 Protein_157 IS66 family transposase -
FOM15_RS27010 150891..151142 + 252 WP_032408900.1 aldo/keto reductase -
FOM15_RS27015 151635..152855 - 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
FOM15_RS27020 152889..153398 - 510 WP_148053329.1 GNAT family N-acetyltransferase Toxin
FOM15_RS27025 153386..153652 - 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
FOM15_RS27030 153849..154007 + 159 WP_014386184.1 type I toxin-antitoxin system Hok family toxin -
FOM15_RS27035 154251..154736 - 486 WP_014386185.1 hypothetical protein -
FOM15_RS27040 154926..155198 + 273 WP_032408902.1 hypothetical protein -
FOM15_RS27045 155195..155545 + 351 WP_014386186.1 hypothetical protein -
FOM15_RS27060 156182..156508 + 327 WP_014386187.1 hypothetical protein -
FOM15_RS27065 156570..156782 + 213 WP_014386188.1 hypothetical protein -
FOM15_RS27070 156793..157017 + 225 WP_014386189.1 hypothetical protein -
FOM15_RS27075 157098..157418 + 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
FOM15_RS27080 157408..157686 + 279 WP_004152721.1 helix-turn-helix domain-containing protein -
FOM15_RS27085 157687..158100 + 414 WP_013023817.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 - 1..202623 202623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18421.40 Da        Isoelectric Point: 9.2603

>T134686 WP_148053329.1 NZ_CP041928:c153398-152889 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLG
LPLLWWLKA

Download         Length: 510 bp

>T134686 NZ_CP041928:c153398-152889 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGGGT
CTTCCCTTGTTGTGGTGGCTGAAGGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT134686 WP_014386183.1 NZ_CP041928:c153652-153386 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp

>AT134686 NZ_CP041928:c153652-153386 [Klebsiella pneumoniae]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References