Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 51839..52575 Replicon plasmid pSECR18-2374A
Accession NZ_CP041928
Organism Klebsiella pneumoniae strain 18-2374

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag FOM15_RS26430 Protein ID WP_003026803.1
Coordinates 51839..52321 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag FOM15_RS26435 Protein ID WP_003026799.1
Coordinates 52309..52575 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOM15_RS26415 48296..49642 - 1347 WP_020314316.1 ISNCY family transposase -
FOM15_RS26420 49838..50236 - 399 WP_032422684.1 helix-turn-helix domain-containing protein -
FOM15_RS26425 50285..51631 - 1347 WP_077255522.1 ISNCY family transposase -
FOM15_RS26430 51839..52321 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
FOM15_RS26435 52309..52575 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
FOM15_RS26440 52751..53005 - 255 WP_004152108.1 hypothetical protein -
FOM15_RS26445 53081..53338 - 258 WP_004152107.1 hypothetical protein -
FOM15_RS26450 53387..53590 - 204 WP_004152106.1 hemolysin expression modulator Hha -
FOM15_RS26455 53624..53992 - 369 WP_004152105.1 hypothetical protein -
FOM15_RS26460 54036..54530 - 495 WP_004152104.1 DNA-binding protein -
FOM15_RS26465 54561..55136 - 576 WP_004152103.1 hypothetical protein -
FOM15_RS26470 55124..55393 - 270 WP_004152102.1 hypothetical protein -
FOM15_RS26475 55751..56101 + 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
FOM15_RS26480 56151..56513 + 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 - 1..202623 202623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T134684 WP_003026803.1 NZ_CP041928:c52321-51839 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T134684 NZ_CP041928:c52321-51839 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT134684 WP_003026799.1 NZ_CP041928:c52575-52309 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT134684 NZ_CP041928:c52575-52309 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References