Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802291..802948 Replicon chromosome
Accession NZ_CP041927
Organism Klebsiella pneumoniae strain 18-2374

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FOM15_RS03985 Protein ID WP_002916310.1
Coordinates 802291..802701 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FOM15_RS03990 Protein ID WP_002916312.1
Coordinates 802682..802948 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOM15_RS03965 798291..800024 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
FOM15_RS03970 800030..800743 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOM15_RS03975 800766..801662 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FOM15_RS03980 801763..802284 + 522 WP_004144730.1 flavodoxin FldB -
FOM15_RS03985 802291..802701 - 411 WP_002916310.1 protein YgfX Toxin
FOM15_RS03990 802682..802948 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FOM15_RS03995 803194..804177 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
FOM15_RS04000 804328..804987 - 660 WP_002916317.1 hemolysin III family protein -
FOM15_RS04005 805151..805462 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FOM15_RS04010 805512..806240 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FOM15_RS04015 806359..807792 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T134667 WP_002916310.1 NZ_CP041927:c802701-802291 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T134667 NZ_CP041927:c802701-802291 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT134667 WP_002916312.1 NZ_CP041927:c802948-802682 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT134667 NZ_CP041927:c802948-802682 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References