134666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 53777..54270 Replicon plasmid unnamed1
Accession NZ_CP041926
Organism Klebsiella aerogenes strain Ka37751

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag FPV33_RS25405 Protein ID WP_001230709.1
Coordinates 54016..54270 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag FPV33_RS25400 Protein ID WP_000151456.1
Coordinates 53777..54019 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV33_RS25365 48879..49202 - 324 WP_000427403.1 hypothetical protein -
FPV33_RS25375 49783..50112 - 330 WP_000855120.1 hypothetical protein -
FPV33_RS25385 50871..52133 + 1263 WP_000608644.1 IS1380-like element ISEc9 family transposase -
FPV33_RS25390 52386..53261 + 876 WP_087587947.1 class A extended-spectrum beta-lactamase CTX-M-199 -
FPV33_RS25395 53308..53640 - 333 WP_001393253.1 WbuC family cupin fold metalloprotein -
FPV33_RS25400 53777..54019 - 243 WP_000151456.1 hypothetical protein Antitoxin
FPV33_RS25405 54016..54270 - 255 WP_001230709.1 hypothetical protein Toxin
FPV33_RS25410 54267..54809 - 543 WP_001083904.1 hypothetical protein -
FPV33_RS25415 54913..55428 - 516 WP_001025393.1 J domain-containing protein -
FPV33_RS25625 55425..55778 - 354 WP_157806643.1 hypothetical protein -
FPV33_RS25420 56015..56680 + 666 WP_015387337.1 P-loop NTPase -
FPV33_RS25630 56754..57038 + 285 WP_001162371.1 hypothetical protein -
FPV33_RS25430 57056..57652 - 597 WP_000125165.1 hypothetical protein -
FPV33_RS25435 57801..57962 - 162 WP_001434039.1 type I toxin-antitoxin system Hok family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 / blaCTX-M-199 - 1..65845 65845
- flank IS/Tn blaCTX-M-199 - 50871..53261 2390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T134666 WP_001230709.1 NZ_CP041926:c54270-54016 [Klebsiella aerogenes]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T134666 NZ_CP041926:c54270-54016 [Klebsiella aerogenes]
ATGAGAAAAAATAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT134666 WP_000151456.1 NZ_CP041926:c54019-53777 [Klebsiella aerogenes]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT134666 NZ_CP041926:c54019-53777 [Klebsiella aerogenes]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References