Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3906428..3907047 Replicon chromosome
Accession NZ_CP041925
Organism Klebsiella aerogenes strain Ka37751

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag FPV33_RS18940 Protein ID WP_015367918.1
Coordinates 3906829..3907047 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag FPV33_RS18935 Protein ID WP_015367917.1
Coordinates 3906428..3906802 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV33_RS18925 3901587..3902786 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FPV33_RS18930 3902809..3905955 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
FPV33_RS18935 3906428..3906802 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
FPV33_RS18940 3906829..3907047 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
FPV33_RS18945 3907179..3907742 + 564 WP_143830335.1 maltose O-acetyltransferase -
FPV33_RS18950 3907868..3908332 + 465 WP_015367920.1 YlaC family protein -
FPV33_RS18955 3908307..3909761 - 1455 WP_045388538.1 PLP-dependent aminotransferase family protein -
FPV33_RS18960 3909864..3910574 + 711 WP_063402122.1 GNAT family N-acetyltransferase -
FPV33_RS18965 3910571..3910711 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FPV33_RS18970 3910714..3910974 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T134662 WP_015367918.1 NZ_CP041925:3906829-3907047 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T134662 NZ_CP041925:3906829-3907047 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT134662 WP_015367917.1 NZ_CP041925:3906428-3906802 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT134662 NZ_CP041925:3906428-3906802 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCTCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGACGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References