Detailed information of TA system TA134652

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 859646..860303
• Replicon: chromosome
• Accession: NZ_CP041925
• Organism: Klebsiella aerogenes strain Ka37751

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FPV33_RS04225
• Protein ID: WP_045414364.1
• Coordinates: 859893..860303 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0H3FJK6
• Locus tag: FPV33_RS04220
• Protein ID: WP_015369791.1
• Coordinates: 859646..859912 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPV33_RS04195	854769..856202	-	1434	WP_032712496.1	6-phospho-beta-glucosidase BglA	-
FPV33_RS04200	856316..857050	-	735	WP_015703423.1	MurR/RpiR family transcriptional regulator	-
FPV33_RS04205	857101..857412	+	312	WP_015703422.1	N(4)-acetylcytidine aminohydrolase	-
FPV33_RS04210	857577..858236	+	660	WP_008806429.1	hemolysin III family protein	-
FPV33_RS04215	858439..859422	-	984	WP_015369790.1	tRNA-modifying protein YgfZ	-
FPV33_RS04220	859646..859912	+	267	WP_015369791.1	FAD assembly factor SdhE	Antitoxin
FPV33_RS04225	859893..860303	+	411	WP_045414364.1	protein YgfX	Toxin
FPV33_RS04230	860311..860832	-	522	WP_015369793.1	flavodoxin FldB	-
FPV33_RS04235	860933..861829	+	897	WP_015703420.1	site-specific tyrosine recombinase XerD	-
FPV33_RS04240	861852..862565	+	714	WP_015369795.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FPV33_RS04245	862571..864304	+	1734	WP_063445946.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15905.72 Da
• Isoelectric Point: 10.0200

>T134652 WP_045414364.1 NZ_CP041925:859893-860303 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVMQKPAHD

Nucleotide

• Length: 411 bp

>T134652 NZ_CP041925:859893-860303 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGTATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGATGCAAAAACCGG
CGCACGACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10579.09 Da
• Isoelectric Point: 5.6963

>AT134652 WP_015369791.1 NZ_CP041925:859646-859912 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT134652 NZ_CP041925:859646-859912 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3FJK6