Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 274351..274982 | Replicon | chromosome |
Accession | NZ_CP041925 | ||
Organism | Klebsiella aerogenes strain Ka37751 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0H3FL31 |
Locus tag | FPV33_RS01245 | Protein ID | WP_015703741.1 |
Coordinates | 274351..274626 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A0H3FNK6 |
Locus tag | FPV33_RS01250 | Protein ID | WP_015703740.1 |
Coordinates | 274623..274982 (+) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPV33_RS01225 | 269579..269914 | + | 336 | WP_015703743.1 | universal stress protein UspB | - |
FPV33_RS01230 | 269980..271476 | - | 1497 | WP_015369272.1 | inorganic phosphate transporter PitA | - |
FPV33_RS01235 | 271707..272900 | + | 1194 | WP_063446422.1 | NAD(P)/FAD-dependent oxidoreductase | - |
FPV33_RS01240 | 272941..273954 | - | 1014 | WP_015369274.1 | magnesium transporter | - |
FPV33_RS01245 | 274351..274626 | + | 276 | WP_015703741.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
FPV33_RS01250 | 274623..274982 | + | 360 | WP_015703740.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
FPV33_RS01255 | 275010..275411 | - | 402 | WP_047079886.1 | nickel-responsive transcriptional regulator NikR | - |
FPV33_RS01260 | 275399..276190 | - | 792 | WP_063446423.1 | nickel import ATP-binding protein NikE | - |
FPV33_RS01265 | 276187..276951 | - | 765 | WP_032715258.1 | nickel import ATP-binding protein NikD | - |
FPV33_RS01270 | 276951..277784 | - | 834 | WP_063446424.1 | nickel ABC transporter permease subunit NikC | - |
FPV33_RS01275 | 277781..278725 | - | 945 | WP_063446428.1 | nickel ABC transporter permease subunit NikB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10258.89 Da Isoelectric Point: 10.4888
>T134651 WP_015703741.1 NZ_CP041925:274351-274626 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP
Download Length: 276 bp
>T134651 NZ_CP041925:274351-274626 [Klebsiella aerogenes]
ATGGAGCAGCAGGTTTTATCTTTACGTAAAAAACAGCGCAACACGCTGGAGCAGCTGTTTAAAACCCCCGTGCCGCAGGG
TATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGTGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCACCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA
ATGGAGCAGCAGGTTTTATCTTTACGTAAAAAACAGCGCAACACGCTGGAGCAGCTGTTTAAAACCCCCGTGCCGCAGGG
TATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGTGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCACCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13305.02 Da Isoelectric Point: 4.3472
>AT134651 WP_015703740.1 NZ_CP041925:274623-274982 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA
Download Length: 360 bp
>AT134651 NZ_CP041925:274623-274982 [Klebsiella aerogenes]
ATGATCAAACCTAAAACGCCAAATTCAATGGAGATTGCCGGGCAGCCTGCTGTTATTAACTACGTGCCTGAACTCAATGC
ATTCCGCGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTTGCTGATTGTCGTGAAGCGGGCATCGAGCCTTATGCTCAGCCGGAAAAGCTGAAAACC
TTCACATTGCGCTATCCTGAATCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA
ATGATCAAACCTAAAACGCCAAATTCAATGGAGATTGCCGGGCAGCCTGCTGTTATTAACTACGTGCCTGAACTCAATGC
ATTCCGCGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTTGCTGATTGTCGTGAAGCGGGCATCGAGCCTTATGCTCAGCCGGAAAAGCTGAAAACC
TTCACATTGCGCTATCCTGAATCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3FL31 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3FNK6 |