Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 274351..274982 Replicon chromosome
Accession NZ_CP041925
Organism Klebsiella aerogenes strain Ka37751

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag FPV33_RS01245 Protein ID WP_015703741.1
Coordinates 274351..274626 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag FPV33_RS01250 Protein ID WP_015703740.1
Coordinates 274623..274982 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV33_RS01225 269579..269914 + 336 WP_015703743.1 universal stress protein UspB -
FPV33_RS01230 269980..271476 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
FPV33_RS01235 271707..272900 + 1194 WP_063446422.1 NAD(P)/FAD-dependent oxidoreductase -
FPV33_RS01240 272941..273954 - 1014 WP_015369274.1 magnesium transporter -
FPV33_RS01245 274351..274626 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
FPV33_RS01250 274623..274982 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FPV33_RS01255 275010..275411 - 402 WP_047079886.1 nickel-responsive transcriptional regulator NikR -
FPV33_RS01260 275399..276190 - 792 WP_063446423.1 nickel import ATP-binding protein NikE -
FPV33_RS01265 276187..276951 - 765 WP_032715258.1 nickel import ATP-binding protein NikD -
FPV33_RS01270 276951..277784 - 834 WP_063446424.1 nickel ABC transporter permease subunit NikC -
FPV33_RS01275 277781..278725 - 945 WP_063446428.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T134651 WP_015703741.1 NZ_CP041925:274351-274626 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T134651 NZ_CP041925:274351-274626 [Klebsiella aerogenes]
ATGGAGCAGCAGGTTTTATCTTTACGTAAAAAACAGCGCAACACGCTGGAGCAGCTGTTTAAAACCCCCGTGCCGCAGGG
TATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGTGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCACCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT134651 WP_015703740.1 NZ_CP041925:274623-274982 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT134651 NZ_CP041925:274623-274982 [Klebsiella aerogenes]
ATGATCAAACCTAAAACGCCAAATTCAATGGAGATTGCCGGGCAGCCTGCTGTTATTAACTACGTGCCTGAACTCAATGC
ATTCCGCGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTTGCTGATTGTCGTGAAGCGGGCATCGAGCCTTATGCTCAGCCGGAAAAGCTGAAAACC
TTCACATTGCGCTATCCTGAATCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References