Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 25221..25743 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP041921 | ||
| Organism | Escherichia coli strain Ec40743 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | FPV29_RS23910 | Protein ID | WP_000638823.1 |
| Coordinates | 25221..25502 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | FPV29_RS23915 | Protein ID | WP_000121741.1 |
| Coordinates | 25492..25743 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPV29_RS23875 | 21370..21690 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| FPV29_RS23880 | 21761..21949 | - | 189 | WP_050567133.1 | hypothetical protein | - |
| FPV29_RS23885 | 22051..22635 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| FPV29_RS23890 | 22656..23054 | - | 399 | WP_072643816.1 | hypothetical protein | - |
| FPV29_RS23895 | 23173..23610 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| FPV29_RS23900 | 23616..24851 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| FPV29_RS23905 | 24854..25153 | - | 300 | WP_000835764.1 | IncN plasmid KikA protein | - |
| FPV29_RS23910 | 25221..25502 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FPV29_RS23915 | 25492..25743 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| FPV29_RS23920 | 25843..26478 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| FPV29_RS23925 | 26551..26838 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| FPV29_RS23930 | 26851..27105 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| FPV29_RS23935 | 27107..27748 | - | 642 | WP_001425343.1 | conjugal transfer protein TrbJ | - |
| FPV29_RS23940 | 27754..28749 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| FPV29_RS23945 | 28753..29010 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| FPV29_RS23950 | 29007..29309 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| FPV29_RS23955 | 29290..29547 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| FPV29_RS23960 | 29580..30026 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| FPV29_RS24950 | 30037..30207 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| FPV29_RS23965 | 30211..30654 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-199 / mcr-1.1 | - | 1..65845 | 65845 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T134647 WP_000638823.1 NZ_CP041921:c25502-25221 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T134647 NZ_CP041921:c25502-25221 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT134647 WP_000121741.1 NZ_CP041921:c25743-25492 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT134647 NZ_CP041921:c25743-25492 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|