Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3207113..3207800 Replicon chromosome
Accession NZ_CP041875
Organism Mycobacterium tuberculosis strain 1-0007P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag FPJ31_RS15160 Protein ID WP_003414624.1
Coordinates 3207357..3207800 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag FPJ31_RS15155 Protein ID WP_003414620.1
Coordinates 3207113..3207370 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ31_RS15135 3202433..3203287 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
FPJ31_RS15140 3203343..3204506 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FPJ31_RS15145 3204523..3205737 - 1215 WP_003414610.1 zinc metalloprotease Rip -
FPJ31_RS15150 3205745..3206986 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
FPJ31_RS15155 3207113..3207370 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ31_RS15160 3207357..3207800 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ31_RS15165 3207880..3208542 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
FPJ31_RS15170 3208638..3208829 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ31_RS15175 3209161..3210909 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
FPJ31_RS15180 3211005..3211586 + 582 WP_003414644.1 fasciclin domain-containing protein -
FPJ31_RS15185 3211686..3211952 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T134548 WP_003414624.1 NZ_CP041875:3207357-3207800 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T134548 NZ_CP041875:3207357-3207800 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT134548 WP_003414620.1 NZ_CP041875:3207113-3207370 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT134548 NZ_CP041875:3207113-3207370 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References