Detailed information of TA system TA134507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 759257..759890
• Replicon: chromosome
• Accession: NZ_CP041875
• Organism: Mycobacterium tuberculosis strain 1-0007P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ31_RS03470
• Protein ID: WP_015629650.1
• Coordinates: 759257..759640 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ56
• Locus tag: FPJ31_RS03475
• Protein ID: WP_003403368.1
• Coordinates: 759735..759890 (-)
• Length: 52 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ31_RS03445	754548..755084	+	537	WP_003403341.1	50S ribosomal protein L10	-
FPJ31_RS03450	755121..755513	+	393	WP_003403353.1	50S ribosomal protein L7/L12	-
FPJ31_RS03455	755506..756201	-	696	WP_003403355.1	TetR/AcrR family transcriptional regulator	-
FPJ31_RS03460	756324..757778	+	1455	WP_049955505.1	carotenoid cleavage oxygenase	-
FPJ31_RS03465	757859..758869	+	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
FPJ31_RS03470	759257..759640	-	384	WP_015629650.1	hypothetical protein	Toxin
FPJ31_RS03475	759735..759890	-	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ31_RS03480	759966..760682	-	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
FPJ31_RS03485	760958..761266	-	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FPJ31_RS03490	761253..761498	-	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	-
FPJ31_RS03495	761608..762045	-	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	-
FPJ31_RS03500	762042..762296	-	255	WP_003911263.1	antitoxin VapB7	-
FPJ31_RS03505	762410..764773	+	2364	WP_003403397.1	arylsulfatase AtsD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13886.68 Da
• Isoelectric Point: 6.0803

>T134507 WP_015629650.1 NZ_CP041875:c759640-759257 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRLIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Nucleotide

• Length: 384 bp

>T134507 NZ_CP041875:c759640-759257 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTTGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 52 a.a.
• Molecular weight: 5872.72 Da
• Isoelectric Point: 5.7734

>AT134507 WP_003403368.1 NZ_CP041875:c759890-759735 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Nucleotide

• Length: 156 bp

>AT134507 NZ_CP041875:c759890-759735 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BSF8