Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 839131..839840 Replicon chromosome
Accession NZ_CP041874
Organism Mycobacterium tuberculosis strain 1-0009P6C4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPJ32_RS03930 Protein ID WP_116298772.1
Coordinates 839433..839840 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag FPJ32_RS03925 Protein ID WP_003403834.1
Coordinates 839131..839388 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ32_RS03920 836767..839040 + 2274 WP_016330384.1 PE family protein -
FPJ32_RS03925 839131..839388 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ32_RS03930 839433..839840 + 408 WP_116298772.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ32_RS03935 839930..840104 - 175 Protein_778 transposase -
FPJ32_RS03940 840217..840462 + 246 WP_003403841.1 hypothetical protein -
FPJ32_RS03945 840531..841415 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
FPJ32_RS03950 841426..842588 - 1163 Protein_781 acyl-CoA dehydrogenase family protein -
FPJ32_RS03955 842595..844127 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-126)

Antitoxin

(2-36)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 15026.31 Da        Isoelectric Point: 8.0185

>T134451 WP_116298772.1 NZ_CP041874:839433-839840 [Mycobacterium tuberculosis]
VLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPR
HLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 408 bp

>T134451 NZ_CP041874:839433-839840 [Mycobacterium tuberculosis]
GTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTTCGATCGACTGCTCGCGGCTGA
CGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATCGACGCATCTTCGAGATTCCGT
CACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTTCCGACGAACCCCGGTCCCAGA
CACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACCTGACGCGGTACTCGCGGCCAT
AGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCTCGGTGCGCCACATTCGCCCGC
CGCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT134451 WP_003403834.1 NZ_CP041874:839131-839388 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT134451 NZ_CP041874:839131-839388 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References