Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 839131..839840 | Replicon | chromosome |
Accession | NZ_CP041874 | ||
Organism | Mycobacterium tuberculosis strain 1-0009P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | FPJ32_RS03930 | Protein ID | WP_116298772.1 |
Coordinates | 839433..839840 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TEX4 |
Locus tag | FPJ32_RS03925 | Protein ID | WP_003403834.1 |
Coordinates | 839131..839388 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ32_RS03920 | 836767..839040 | + | 2274 | WP_016330384.1 | PE family protein | - |
FPJ32_RS03925 | 839131..839388 | + | 258 | WP_003403834.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
FPJ32_RS03930 | 839433..839840 | + | 408 | WP_116298772.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FPJ32_RS03935 | 839930..840104 | - | 175 | Protein_778 | transposase | - |
FPJ32_RS03940 | 840217..840462 | + | 246 | WP_003403841.1 | hypothetical protein | - |
FPJ32_RS03945 | 840531..841415 | - | 885 | WP_003403844.1 | 3-hydroxyisobutyrate dehydrogenase | - |
FPJ32_RS03950 | 841426..842588 | - | 1163 | Protein_781 | acyl-CoA dehydrogenase family protein | - |
FPJ32_RS03955 | 842595..844127 | - | 1533 | WP_003403847.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15026.31 Da Isoelectric Point: 8.0185
>T134451 WP_116298772.1 NZ_CP041874:839433-839840 [Mycobacterium tuberculosis]
VLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPR
HLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL
VLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPR
HLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL
Download Length: 408 bp
>T134451 NZ_CP041874:839433-839840 [Mycobacterium tuberculosis]
GTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTTCGATCGACTGCTCGCGGCTGA
CGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATCGACGCATCTTCGAGATTCCGT
CACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTTCCGACGAACCCCGGTCCCAGA
CACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACCTGACGCGGTACTCGCGGCCAT
AGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCTCGGTGCGCCACATTCGCCCGC
CGCTCTAG
GTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTTCGATCGACTGCTCGCGGCTGA
CGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATCGACGCATCTTCGAGATTCCGT
CACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTTCCGACGAACCCCGGTCCCAGA
CACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACCTGACGCGGTACTCGCGGCCAT
AGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCTCGGTGCGCCACATTCGCCCGC
CGCTCTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9114.28 Da Isoelectric Point: 10.6530
>AT134451 WP_003403834.1 NZ_CP041874:839131-839388 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK
Download Length: 258 bp
>AT134451 NZ_CP041874:839131-839388 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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