Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3786891..3787420 Replicon chromosome
Accession NZ_CP041871
Organism Mycobacterium tuberculosis strain 1-0021P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPJ35_RS17650 Protein ID WP_003417760.1
Coordinates 3787163..3787420 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPJ35_RS17645 Protein ID WP_003417757.1
Coordinates 3786891..3787166 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ35_RS17625 3783689..3785126 - 1438 Protein_3481 FAD-binding oxidoreductase -
FPJ35_RS17630 3785229..3785618 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPJ35_RS17635 3785632..3785925 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPJ35_RS17640 3785922..3786767 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPJ35_RS17645 3786891..3787166 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPJ35_RS17650 3787163..3787420 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPJ35_RS17655 3787462..3788652 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPJ35_RS17660 3788769..3789136 + 368 Protein_3488 FHA domain-containing protein -
FPJ35_RS17665 3789133..3789684 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPJ35_RS17670 3789691..3790272 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPJ35_RS17675 3790253..3790621 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPJ35_RS17680 3790599..3790991 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T134311 WP_003417760.1 NZ_CP041871:3787163-3787420 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T134311 NZ_CP041871:3787163-3787420 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT134311 WP_003417757.1 NZ_CP041871:3786891-3787166 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT134311 NZ_CP041871:3786891-3787166 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCGGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References