Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2880181..2880812 | Replicon | chromosome |
Accession | NZ_CP041871 | ||
Organism | Mycobacterium tuberculosis strain 1-0021P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | FPJ35_RS13405 | Protein ID | WP_003413174.1 |
Coordinates | 2880435..2880812 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | FPJ35_RS13400 | Protein ID | WP_003413167.1 |
Coordinates | 2880181..2880438 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ35_RS13370 | 2876095..2876409 | + | 315 | WP_009937839.1 | hypothetical protein | - |
FPJ35_RS13375 | 2876705..2877916 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
FPJ35_RS13380 | 2878043..2878702 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
FPJ35_RS13385 | 2878699..2879361 | + | 663 | WP_023643170.1 | hypothetical protein | - |
FPJ35_RS13390 | 2879358..2879636 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
FPJ35_RS13395 | 2879729..2880142 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
FPJ35_RS13400 | 2880181..2880438 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
FPJ35_RS13405 | 2880435..2880812 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FPJ35_RS13410 | 2880828..2881202 | - | 375 | WP_003413177.1 | hypothetical protein | - |
FPJ35_RS13415 | 2881302..2881697 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
FPJ35_RS13420 | 2881694..2881939 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
FPJ35_RS13425 | 2882350..2882769 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
FPJ35_RS13430 | 2882781..2883590 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
FPJ35_RS13435 | 2883587..2884840 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
FPJ35_RS13440 | 2884833..2885345 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T134298 WP_003413174.1 NZ_CP041871:2880435-2880812 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T134298 NZ_CP041871:2880435-2880812 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT134298 WP_003413167.1 NZ_CP041871:2880181-2880438 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT134298 NZ_CP041871:2880181-2880438 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |