Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2879729..2880438 Replicon chromosome
Accession NZ_CP041871
Organism Mycobacterium tuberculosis strain 1-0021P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ35_RS13395 Protein ID WP_003413164.1
Coordinates 2879729..2880142 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ35_RS13400 Protein ID WP_003413167.1
Coordinates 2880181..2880438 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ35_RS13365 2874782..2875987 - 1206 WP_003413027.1 chorismate synthase -
FPJ35_RS13370 2876095..2876409 + 315 WP_009937839.1 hypothetical protein -
FPJ35_RS13375 2876705..2877916 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ35_RS13380 2878043..2878702 + 660 WP_003900846.1 LppA family lipoprotein -
FPJ35_RS13385 2878699..2879361 + 663 WP_023643170.1 hypothetical protein -
FPJ35_RS13390 2879358..2879636 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ35_RS13395 2879729..2880142 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ35_RS13400 2880181..2880438 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ35_RS13405 2880435..2880812 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ35_RS13410 2880828..2881202 - 375 WP_003413177.1 hypothetical protein -
FPJ35_RS13415 2881302..2881697 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ35_RS13420 2881694..2881939 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ35_RS13425 2882350..2882769 - 420 WP_003413190.1 A24 family peptidase -
FPJ35_RS13430 2882781..2883590 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ35_RS13435 2883587..2884840 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ35_RS13440 2884833..2885345 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T134297 WP_003413164.1 NZ_CP041871:2879729-2880142 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T134297 NZ_CP041871:2879729-2880142 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT134297 WP_003413167.1 NZ_CP041871:2880181-2880438 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT134297 NZ_CP041871:2880181-2880438 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References