Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 368010..368536 Replicon chromosome
Accession NZ_CP041871
Organism Mycobacterium tuberculosis strain 1-0021P6C4

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag FPJ35_RS01600 Protein ID WP_015629470.1
Coordinates 368234..368536 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag FPJ35_RS01595 Protein ID WP_003401555.1
Coordinates 368010..368237 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ35_RS01580 363703..364506 - 804 WP_003401540.1 hypothetical protein -
FPJ35_RS01585 364516..365913 - 1398 WP_003401544.1 sulfatase -
FPJ35_RS01590 366092..367867 + 1776 WP_010886074.1 PE family protein -
FPJ35_RS01595 368010..368237 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ35_RS01600 368234..368536 + 303 WP_015629470.1 toxin-antitoxin system toxin Toxin
FPJ35_RS01605 368584..368805 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
FPJ35_RS01610 368802..369227 + 426 WP_003401566.1 PIN domain nuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10472.19 Da        Isoelectric Point: 4.9609

>T134256 WP_015629470.1 NZ_CP041871:368234-368536 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRATDTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T134256 NZ_CP041871:368234-368536 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCACGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT134256 WP_003401555.1 NZ_CP041871:368010-368237 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT134256 NZ_CP041871:368010-368237 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References