Detailed information of TA system TA134218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1391232..1391791
• Replicon: chromosome
• Accession: NZ_CP041870
• Organism: Mycobacterium tuberculosis strain 1-0023P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FPJ36_RS06530
• Protein ID: WP_003898789.1
• Coordinates: 1391232..1391525 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FPJ36_RS06535
• Protein ID: WP_003406322.1
• Coordinates: 1391522..1391791 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ36_RS06505	1386930..1387190	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FPJ36_RS06510	1387187..1387618	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FPJ36_RS06515	1387641..1389224	-	1584	WP_009940130.1	PE family protein	-
FPJ36_RS06520	1389404..1390264	+	861	WP_003900301.1	hypothetical protein	-
FPJ36_RS06525	1390345..1391175	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ36_RS06530	1391232..1391525	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FPJ36_RS06535	1391522..1391791	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ36_RS06540	1391904..1395599	-	3696	WP_104857299.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FPJ36_RS06545	1395741..1396529	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T134218 WP_003898789.1 NZ_CP041870:c1391525-1391232 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T134218 NZ_CP041870:c1391525-1391232 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT134218 WP_003406322.1 NZ_CP041870:c1391791-1391522 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT134218 NZ_CP041870:c1391791-1391522 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2