Detailed information of TA system TA134196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 363838..364364
• Replicon: chromosome
• Accession: NZ_CP041870
• Organism: Mycobacterium tuberculosis strain 1-0023P6C4

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: FPJ36_RS01580
• Protein ID: WP_003401560.1
• Coordinates: 364062..364364 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: -
• Locus tag: FPJ36_RS01575
• Protein ID: WP_031665974.1
• Coordinates: 363838..364065 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ36_RS01560	359531..360334	-	804	WP_003401540.1	hypothetical protein	-
FPJ36_RS01565	360344..361741	-	1398	WP_003401544.1	sulfatase	-
FPJ36_RS01570	361920..363695	+	1776	WP_010886074.1	PE family protein	-
FPJ36_RS01575	363838..364065	+	228	WP_031665974.1	ribbon-helix-helix protein, CopG family	Antitoxin
FPJ36_RS01580	364062..364364	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
FPJ36_RS01585	364412..364633	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
FPJ36_RS01590	364630..365055	+	426	WP_003401566.1	PIN domain nuclease	-
FPJ36_RS01595	365191..365823	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
FPJ36_RS01600	365820..366728	+	909	WP_003900117.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-40)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T134196 WP_003401560.1 NZ_CP041870:364062-364364 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T134196 NZ_CP041870:364062-364364 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8148.24 Da
• Isoelectric Point: 7.0084

>AT134196 WP_031665974.1 NZ_CP041870:363838-364065 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHMRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT134196 NZ_CP041870:363838-364065 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACATGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA