134089

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 767972..768512 Replicon chromosome
Accession NZ_CP041868
Organism Mycobacterium tuberculosis strain 1-0030P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag FPJ38_RS03535 Protein ID WP_003403376.1
Coordinates 767972..768280 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FPJ38_RS03540 Protein ID WP_003403381.1
Coordinates 768267..768512 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ38_RS03510 763287..764792 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FPJ38_RS03515 764873..765883 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
FPJ38_RS03520 766271..766654 - 384 WP_003403365.1 ribonuclease VapC6 -
FPJ38_RS03525 766749..766904 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ38_RS03530 766980..767696 - 717 WP_031664746.1 CPBP family intramembrane metalloprotease -
FPJ38_RS03535 767972..768280 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPJ38_RS03540 768267..768512 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ38_RS03545 768622..769059 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FPJ38_RS03550 769056..769310 - 255 WP_003911263.1 antitoxin VapB7 -
FPJ38_RS03555 769424..771787 + 2364 WP_003403397.1 arylsulfatase AtsD -
FPJ38_RS03560 771850..772176 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ38_RS03565 772088..772426 + 339 WP_003403405.1 PIN domain-containing protein -
FPJ38_RS03570 772423..772596 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T134089 WP_003403376.1 NZ_CP041868:c768280-767972 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T134089 NZ_CP041868:c768280-767972 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT134089 WP_003403381.1 NZ_CP041868:c768512-768267 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT134089 NZ_CP041868:c768512-768267 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References