Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2193629..2194173 Replicon chromosome
Accession NZ_CP041867
Organism Mycobacterium tuberculosis strain 1-0031P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPJ39_RS10160 Protein ID WP_003409896.1
Coordinates 2193629..2193925 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ39_RS10165 Protein ID WP_003409899.1
Coordinates 2193922..2194173 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ39_RS10105 2188662..2189012 - 351 WP_003409871.1 hypothetical protein -
FPJ39_RS10110 2189023..2189925 - 903 WP_003899097.1 hypothetical protein -
FPJ39_RS10115 2189946..2190137 - 192 WP_003409876.1 hypothetical protein -
FPJ39_RS10120 2190138..2190434 - 297 WP_003409877.1 hypothetical protein -
FPJ39_RS10125 2190674..2190889 + 216 WP_003409878.1 antitoxin -
FPJ39_RS10130 2190886..2191197 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ39_RS10135 2191171..2191692 - 522 WP_003904745.1 hypothetical protein -
FPJ39_RS10140 2191667..2192044 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPJ39_RS10145 2192086..2192535 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPJ39_RS10150 2192532..2193077 + 546 WP_003409891.1 SecB-like chaperone -
FPJ39_RS10155 2192966..2193580 - 615 WP_003901296.1 hypothetical protein -
FPJ39_RS10160 2193629..2193925 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ39_RS10165 2193922..2194173 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPJ39_RS10170 2194160..2194654 + 495 WP_003899099.1 hypothetical protein -
FPJ39_RS10175 2194814..2195221 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ39_RS10180 2195225..2195497 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ39_RS10185 2195530..2196750 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPJ39_RS10190 2197649..2198446 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T134047 WP_003409896.1 NZ_CP041867:c2193925-2193629 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T134047 NZ_CP041867:c2193925-2193629 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT134047 WP_003409899.1 NZ_CP041867:c2194173-2193922 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT134047 NZ_CP041867:c2194173-2193922 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References