Detailed information of TA system TA134011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3704008..3704682
• Replicon: chromosome
• Accession: NZ_CP041866
• Organism: Mycobacterium tuberculosis strain 1-0036P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPJ40_RS17325
• Protein ID: WP_003417282.1
• Coordinates: 3704008..3704436 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPJ40_RS17330
• Protein ID: WP_003417286.1
• Coordinates: 3704440..3704682 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ40_RS17300	3699830..3700231	-	402	WP_003417264.1	cytidine deaminase	-
FPJ40_RS17305	3700372..3700806	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPJ40_RS17310	3700803..3701237	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPJ40_RS17315	3701366..3703138	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPJ40_RS17320	3703138..3703929	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPJ40_RS17325	3704008..3704436	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ40_RS17330	3704440..3704682	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPJ40_RS17335	3704804..3705418	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPJ40_RS17340	3705415..3706080	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPJ40_RS17345	3706081..3706614	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPJ40_RS17350	3706611..3706985	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPJ40_RS17355	3707082..3708146	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T134011 WP_003417282.1 NZ_CP041866:c3704436-3704008 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T134011 NZ_CP041866:c3704436-3704008 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT134011 WP_003417286.1 NZ_CP041866:c3704682-3704440 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT134011 NZ_CP041866:c3704682-3704440 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59