Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 366366..366892 Replicon chromosome
Accession NZ_CP041866
Organism Mycobacterium tuberculosis strain 1-0036P6C4

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag FPJ40_RS01585 Protein ID WP_003401560.1
Coordinates 366590..366892 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag FPJ40_RS01580 Protein ID WP_003401555.1
Coordinates 366366..366593 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ40_RS01565 362059..362862 - 804 WP_003401540.1 hypothetical protein -
FPJ40_RS01570 362872..364269 - 1398 WP_003401544.1 sulfatase -
FPJ40_RS01575 364448..366223 + 1776 WP_010886074.1 PE family protein -
FPJ40_RS01580 366366..366593 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ40_RS01585 366590..366892 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
FPJ40_RS01590 366940..367161 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
FPJ40_RS01595 367158..367583 + 426 WP_003401566.1 PIN domain nuclease -
FPJ40_RS01600 367719..368351 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
FPJ40_RS01605 368348..369256 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T133955 WP_003401560.1 NZ_CP041866:366590-366892 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T133955 NZ_CP041866:366590-366892 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT133955 WP_003401555.1 NZ_CP041866:366366-366593 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT133955 NZ_CP041866:366366-366593 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References