Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2868734..2869443 Replicon chromosome
Accession NZ_CP041865
Organism Mycobacterium tuberculosis strain 1-0039P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ41_RS13325 Protein ID WP_003413164.1
Coordinates 2868734..2869147 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ41_RS13330 Protein ID WP_003413167.1
Coordinates 2869186..2869443 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ41_RS13295 2863788..2864993 - 1206 WP_003413027.1 chorismate synthase -
FPJ41_RS13300 2865101..2865415 + 315 WP_009937839.1 hypothetical protein -
FPJ41_RS13305 2865711..2866922 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ41_RS13310 2867049..2867708 + 660 WP_003902296.1 hypothetical protein -
FPJ41_RS13315 2867705..2868367 + 663 WP_031729659.1 hypothetical protein -
FPJ41_RS13320 2868364..2868641 + 278 Protein_2629 type II toxin-antitoxin system VapB family antitoxin -
FPJ41_RS13325 2868734..2869147 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ41_RS13330 2869186..2869443 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ41_RS13335 2869440..2869817 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ41_RS13340 2869833..2870207 - 375 WP_003413177.1 hypothetical protein -
FPJ41_RS13345 2870307..2870702 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ41_RS13350 2870699..2870944 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ41_RS13355 2871355..2871774 - 420 WP_003413190.1 A24 family peptidase -
FPJ41_RS13360 2871786..2872595 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ41_RS13365 2872592..2873845 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ41_RS13370 2873838..2874350 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T133939 WP_003413164.1 NZ_CP041865:2868734-2869147 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T133939 NZ_CP041865:2868734-2869147 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT133939 WP_003413167.1 NZ_CP041865:2869186-2869443 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT133939 NZ_CP041865:2869186-2869443 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References