Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230775..1231406 Replicon chromosome
Accession NZ_CP041865
Organism Mycobacterium tuberculosis strain 1-0039P6C4

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FPJ41_RS05795 Protein ID WP_003405820.1
Coordinates 1230775..1231086 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FPJ41_RS05800 Protein ID WP_003405836.1
Coordinates 1231086..1231406 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ41_RS05775 1226256..1227680 - 1425 WP_003405805.1 class II fumarate hydratase -
FPJ41_RS05780 1227711..1228799 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
FPJ41_RS05785 1228855..1229499 + 645 WP_003915494.1 DUF4245 domain-containing protein -
FPJ41_RS05790 1229506..1230663 - 1158 WP_003898727.1 AI-2E family transporter -
FPJ41_RS05795 1230775..1231086 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FPJ41_RS05800 1231086..1231406 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FPJ41_RS05805 1231416..1232941 + 1526 Protein_1143 carboxylesterase/lipase family protein -
FPJ41_RS05810 1232959..1234071 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FPJ41_RS05815 1234081..1234338 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FPJ41_RS05820 1234328..1235575 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FPJ41_RS05825 1235572..1236210 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T133917 WP_003405820.1 NZ_CP041865:c1231086-1230775 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T133917 NZ_CP041865:c1231086-1230775 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT133917 WP_003405836.1 NZ_CP041865:c1231406-1231086 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT133917 NZ_CP041865:c1231406-1231086 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References