Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2911710..2912424 Replicon chromosome
Accession NZ_CP041864
Organism Mycobacterium tuberculosis strain 1-0044P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FPJ42_RS13550 Protein ID WP_003413460.1
Coordinates 2911984..2912424 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FPJ42_RS13545 Protein ID WP_003413456.1
Coordinates 2911710..2911997 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ42_RS13510 2907132..2907377 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ42_RS13515 2907374..2907778 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
FPJ42_RS13520 2907995..2908615 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FPJ42_RS13525 2908626..2909120 + 495 WP_003413444.1 DUF2617 family protein -
FPJ42_RS13530 2909117..2909548 + 432 WP_003899390.1 DUF4247 domain-containing protein -
FPJ42_RS13535 2909573..2910031 + 459 WP_003413451.1 DUF350 domain-containing protein -
FPJ42_RS13540 2910028..2911599 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FPJ42_RS13545 2911710..2911997 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FPJ42_RS13550 2911984..2912424 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ42_RS13555 2912445..2913200 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FPJ42_RS13560 2913333..2913929 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FPJ42_RS13565 2913937..2914782 - 846 WP_003413466.1 acyl-CoA thioesterase II -
FPJ42_RS13570 2914811..2915710 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FPJ42_RS13575 2915838..2916512 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T133884 WP_003413460.1 NZ_CP041864:2911984-2912424 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T133884 NZ_CP041864:2911984-2912424 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT133884 WP_003413456.1 NZ_CP041864:2911710-2911997 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT133884 NZ_CP041864:2911710-2911997 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References