Detailed information of TA system TA133834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Txe-YefM
• Location: 3771759..3772288
• Replicon: chromosome
• Accession: NZ_CP041863
• Organism: Mycobacterium tuberculosis strain 1-0045P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TI95
• Locus tag: FPJ43_RS17570
• Protein ID: WP_003417760.1
• Coordinates: 3772031..3772288 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0TI94
• Locus tag: FPJ43_RS17565
• Protein ID: WP_003417757.1
• Coordinates: 3771759..3772034 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ43_RS17545	3768557..3769994	-	1438	Protein_3465	FAD-binding oxidoreductase	-
FPJ43_RS17550	3770097..3770486	+	390	WP_003417745.1	DUF732 domain-containing protein	-
FPJ43_RS17555	3770500..3770793	-	294	WP_003417749.1	DUF3017 domain-containing protein	-
FPJ43_RS17560	3770790..3771635	-	846	WP_003417751.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
FPJ43_RS17565	3771759..3772034	+	276	WP_003417757.1	type II toxin-antitoxin system antitoxin RelJ	Antitoxin
FPJ43_RS17570	3772031..3772288	+	258	WP_003417760.1	Txe/YoeB family addiction module toxin	Toxin
FPJ43_RS17575	3772330..3773520	+	1191	WP_003900033.1	NADH:flavin oxidoreductase	-
FPJ43_RS17580	3773637..3774005	+	369	WP_003417765.1	FHA domain-containing protein	-
FPJ43_RS17585	3774002..3774553	-	552	WP_003417767.1	pentapeptide repeat protein MfpA	-
FPJ43_RS17590	3774560..3775141	-	582	WP_003417769.1	ATP/GTP-binding protein	-
FPJ43_RS17595	3775122..3775490	-	369	WP_003417772.1	DUF742 domain-containing protein	-
FPJ43_RS17600	3775468..3775860	-	393	WP_003417776.1	roadblock/LC7 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10070.30 Da
• Isoelectric Point: 6.4693

>T133834 WP_003417760.1 NZ_CP041863:3772031-3772288 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Nucleotide

• Length: 258 bp

>T133834 NZ_CP041863:3772031-3772288 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10194.35 Da
• Isoelectric Point: 4.6652

>AT133834 WP_003417757.1 NZ_CP041863:3771759-3772034 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Nucleotide

• Length: 276 bp

>AT133834 NZ_CP041863:3771759-3772034 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Toxin

• PDB: 3OEI

Antitoxin

• AlphaFold DB: G0TI94