Detailed information of TA system TA133773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3726936..3727610
• Replicon: chromosome
• Accession: NZ_CP041862
• Organism: Mycobacterium tuberculosis strain 1-0047P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPJ44_RS17455
• Protein ID: WP_003417282.1
• Coordinates: 3726936..3727364 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPJ44_RS17460
• Protein ID: WP_003417286.1
• Coordinates: 3727368..3727610 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ44_RS17430	3722758..3723159	-	402	WP_003417264.1	cytidine deaminase	-
FPJ44_RS17435	3723300..3723734	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPJ44_RS17440	3723731..3724165	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPJ44_RS17445	3724294..3726066	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPJ44_RS17450	3726066..3726857	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPJ44_RS17455	3726936..3727364	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ44_RS17460	3727368..3727610	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPJ44_RS17465	3727732..3728346	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPJ44_RS17470	3728343..3729008	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPJ44_RS17475	3729009..3729542	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPJ44_RS17480	3729539..3729916	-	378	WP_049950930.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPJ44_RS17485	3729915..3731176	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T133773 WP_003417282.1 NZ_CP041862:c3727364-3726936 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T133773 NZ_CP041862:c3727364-3726936 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT133773 WP_003417286.1 NZ_CP041862:c3727610-3727368 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT133773 NZ_CP041862:c3727610-3727368 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59