Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2211576..2212120 Replicon chromosome
Accession NZ_CP041862
Organism Mycobacterium tuberculosis strain 1-0047P6C4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FPJ44_RS10230 Protein ID WP_193076238.1
Coordinates 2211576..2211872 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ44_RS10235 Protein ID WP_003409899.1
Coordinates 2211869..2212120 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ44_RS10175 2206609..2206959 - 351 WP_003409871.1 hypothetical protein -
FPJ44_RS10180 2206970..2207872 - 903 WP_003899097.1 hypothetical protein -
FPJ44_RS10185 2207893..2208084 - 192 WP_003409876.1 hypothetical protein -
FPJ44_RS10190 2208085..2208381 - 297 WP_003409877.1 hypothetical protein -
FPJ44_RS10195 2208621..2208836 + 216 WP_003409878.1 antitoxin -
FPJ44_RS10200 2208833..2209144 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ44_RS10205 2209118..2209639 - 522 WP_003904745.1 hypothetical protein -
FPJ44_RS10210 2209614..2209991 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPJ44_RS10215 2210033..2210482 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPJ44_RS10220 2210479..2211024 + 546 WP_003409891.1 SecB-like chaperone -
FPJ44_RS10225 2210913..2211527 - 615 WP_003901296.1 hypothetical protein -
FPJ44_RS10230 2211576..2211872 - 297 WP_193076238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ44_RS10235 2211869..2212120 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPJ44_RS10240 2212107..2212601 + 495 WP_003899099.1 hypothetical protein -
FPJ44_RS10245 2212761..2213168 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ44_RS10250 2213172..2213444 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ44_RS10255 2213477..2214697 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPJ44_RS10260 2215596..2216393 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11296.70 Da        Isoelectric Point: 7.3211

>T133749 WP_193076238.1 NZ_CP041862:c2211872-2211576 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDRAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T133749 NZ_CP041862:c2211872-2211576 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCGGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT133749 WP_003409899.1 NZ_CP041862:c2212120-2211869 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT133749 NZ_CP041862:c2212120-2211869 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References