Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2364502..2365197 Replicon chromosome
Accession NZ_CP041860
Organism Mycobacterium tuberculosis strain 1-0056P6C4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPJ46_RS10940 Protein ID WP_003905754.1
Coordinates 2364502..2364936 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FPJ46_RS10945 Protein ID WP_003410814.1
Coordinates 2364943..2365197 (-) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ46_RS10930 2360656..2363697 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
FPJ46_RS10935 2363690..2364523 + 834 WP_003899172.1 SWIM zinc finger family protein -
FPJ46_RS10940 2364502..2364936 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ46_RS10945 2364943..2365197 - 255 WP_003410814.1 antitoxin Antitoxin
FPJ46_RS10950 2365213..2365470 - 258 WP_003410816.1 hypothetical protein -
FPJ46_RS10955 2366004..2367265 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPJ46_RS10960 2367305..2367514 + 210 Protein_2167 PE family protein -
FPJ46_RS10965 2367570..2368301 + 732 WP_003900467.1 PPE family protein -
FPJ46_RS10970 2368841..2369587 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T133637 WP_003905754.1 NZ_CP041860:c2364936-2364502 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T133637 NZ_CP041860:c2364936-2364502 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT133637 WP_003410814.1 NZ_CP041860:c2365197-2364943 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT133637 NZ_CP041860:c2365197-2364943 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References