Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2226721..2227619 Replicon chromosome
Accession NZ_CP041860
Organism Mycobacterium tuberculosis strain 1-0056P6C4

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FPJ46_RS10330 Protein ID WP_003410001.1
Coordinates 2226721..2227281 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FPJ46_RS10335 Protein ID WP_003410003.1
Coordinates 2227278..2227619 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ46_RS10300 2221890..2222543 - 654 WP_003409976.1 cutinase Cfp21 -
FPJ46_RS10305 2222658..2222888 + 231 WP_003409980.1 DUF167 domain-containing protein -
FPJ46_RS10310 2222973..2223884 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FPJ46_RS10315 2223993..2224592 + 600 WP_003910883.1 L-lysine exporter -
FPJ46_RS10320 2225008..2225436 + 429 WP_003409992.1 cellulose-binding protein -
FPJ46_RS10325 2225662..2226201 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FPJ46_RS10330 2226721..2227281 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FPJ46_RS10335 2227278..2227619 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FPJ46_RS10340 2227705..2227962 + 258 WP_003410006.1 hypothetical protein -
FPJ46_RS10345 2227863..2228198 - 336 WP_003410009.1 dehydrogenase -
FPJ46_RS10350 2228287..2228631 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FPJ46_RS10355 2228625..2228873 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FPJ46_RS10360 2228973..2231288 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FPJ46_RS10365 2231285..2231557 - 273 WP_003410017.1 DUF1490 family protein -
FPJ46_RS10370 2231610..2231966 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T133632 WP_003410001.1 NZ_CP041860:c2227281-2226721 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T133632 NZ_CP041860:c2227281-2226721 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT133632 WP_003410003.1 NZ_CP041860:c2227619-2227278 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT133632 NZ_CP041860:c2227619-2227278 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References