Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689637..1690253 Replicon chromosome
Accession NZ_CP041860
Organism Mycobacterium tuberculosis strain 1-0056P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FPJ46_RS07850 Protein ID WP_003407593.1
Coordinates 1689936..1690253 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FPJ46_RS07845 Protein ID WP_003900349.1
Coordinates 1689637..1689939 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ46_RS07835 1685532..1687370 + 1839 WP_031676220.1 methylmalonyl-CoA mutase small subunit -
FPJ46_RS07840 1687371..1689623 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FPJ46_RS07845 1689637..1689939 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FPJ46_RS07850 1689936..1690253 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FPJ46_RS07855 1690250..1691254 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FPJ46_RS07860 1691307..1692596 + 1290 WP_003902090.1 serine hydrolase -
FPJ46_RS07865 1692669..1693442 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
FPJ46_RS07870 1693500..1693712 - 213 WP_003898900.1 dodecin family protein -
FPJ46_RS07875 1693722..1693946 - 225 WP_160522526.1 NUDIX domain-containing protein -
FPJ46_RS07880 1694216..1694464 + 249 Protein_1553 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T133624 WP_003407593.1 NZ_CP041860:1689936-1690253 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T133624 NZ_CP041860:1689936-1690253 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT133624 WP_003900349.1 NZ_CP041860:1689637-1689939 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT133624 NZ_CP041860:1689637-1689939 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References