Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2339480..2340116 Replicon chromosome
Accession NZ_CP041859
Organism Mycobacterium tuberculosis strain 1-0061P6C4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FPJ47_RS10805 Protein ID WP_003904769.1
Coordinates 2339706..2340116 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag FPJ47_RS10800 Protein ID WP_003410651.1
Coordinates 2339480..2339713 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ47_RS10790 2335330..2335734 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
FPJ47_RS10795 2335818..2339402 - 3585 WP_003410648.1 cobaltochelatase subunit CobN -
FPJ47_RS10800 2339480..2339713 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
FPJ47_RS10805 2339706..2340116 + 411 WP_003904769.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
FPJ47_RS10810 2340100..2341191 + 1092 WP_003900454.1 precorrin-3B synthase -
FPJ47_RS10815 2341201..2341827 + 627 WP_003410658.1 precorrin-8X methylmutase -
FPJ47_RS10820 2341824..2343350 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
FPJ47_RS10825 2343296..2344519 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14176.35 Da        Isoelectric Point: 9.4835

>T133577 WP_003904769.1 NZ_CP041859:2339706-2340116 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMPAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T133577 NZ_CP041859:2339706-2340116 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCCCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT133577 WP_003410651.1 NZ_CP041859:2339480-2339713 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT133577 NZ_CP041859:2339480-2339713 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References