Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2212833..2213377 | Replicon | chromosome |
| Accession | NZ_CP041859 | ||
| Organism | Mycobacterium tuberculosis strain 1-0061P6C4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FPJ47_RS10200 | Protein ID | WP_003409896.1 |
| Coordinates | 2212833..2213129 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FPJ47_RS10205 | Protein ID | WP_003409899.1 |
| Coordinates | 2213126..2213377 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPJ47_RS10145 | 2207866..2208216 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FPJ47_RS10150 | 2208227..2209129 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| FPJ47_RS10155 | 2209150..2209341 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FPJ47_RS10160 | 2209342..2209638 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FPJ47_RS10165 | 2209878..2210093 | + | 216 | WP_003409878.1 | antitoxin | - |
| FPJ47_RS10170 | 2210090..2210401 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ47_RS10175 | 2210375..2210896 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FPJ47_RS10180 | 2210871..2211248 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FPJ47_RS10185 | 2211290..2211739 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FPJ47_RS10190 | 2211736..2212281 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPJ47_RS10195 | 2212170..2212784 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FPJ47_RS10200 | 2212833..2213129 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FPJ47_RS10205 | 2213126..2213377 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FPJ47_RS10210 | 2213364..2213858 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FPJ47_RS10215 | 2214018..2214425 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ47_RS10220 | 2214429..2214701 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPJ47_RS10225 | 2214734..2215954 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FPJ47_RS10230 | 2216853..2217650 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T133571 WP_003409896.1 NZ_CP041859:c2213129-2212833 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T133571 NZ_CP041859:c2213129-2212833 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT133571 WP_003409899.1 NZ_CP041859:c2213377-2213126 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT133571 NZ_CP041859:c2213377-2213126 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |