Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2189858..2190402 Replicon chromosome
Accession NZ_CP041858
Organism Mycobacterium tuberculosis strain 1-0064P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FPJ48_RS10135 Protein ID WP_003409896.1
Coordinates 2189858..2190154 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FPJ48_RS10140 Protein ID WP_003409899.1
Coordinates 2190151..2190402 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ48_RS10080 2184891..2185241 - 351 WP_003409871.1 hypothetical protein -
FPJ48_RS10085 2185252..2186154 - 903 WP_003899097.1 hypothetical protein -
FPJ48_RS10090 2186175..2186366 - 192 WP_003409876.1 hypothetical protein -
FPJ48_RS10095 2186367..2186663 - 297 WP_003409877.1 hypothetical protein -
FPJ48_RS10100 2186903..2187118 + 216 WP_003409878.1 antitoxin -
FPJ48_RS10105 2187115..2187426 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ48_RS10110 2187400..2187921 - 522 WP_003904745.1 hypothetical protein -
FPJ48_RS10115 2187896..2188273 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FPJ48_RS10120 2188315..2188764 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FPJ48_RS10125 2188761..2189306 + 546 WP_003409891.1 SecB-like chaperone -
FPJ48_RS10130 2189195..2189809 - 615 WP_003901296.1 hypothetical protein -
FPJ48_RS10135 2189858..2190154 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ48_RS10140 2190151..2190402 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FPJ48_RS10145 2190389..2190883 + 495 WP_003899099.1 hypothetical protein -
FPJ48_RS10150 2191043..2191450 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ48_RS10155 2191454..2191726 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ48_RS10160 2191759..2192979 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FPJ48_RS10165 2193878..2194675 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T133510 WP_003409896.1 NZ_CP041858:c2190154-2189858 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T133510 NZ_CP041858:c2190154-2189858 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT133510 WP_003409899.1 NZ_CP041858:c2190402-2190151 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT133510 NZ_CP041858:c2190402-2190151 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References