Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2862434..2863143 Replicon chromosome
Accession NZ_CP041856
Organism Mycobacterium tuberculosis strain 1-0071P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ51_RS13285 Protein ID WP_003413164.1
Coordinates 2862434..2862847 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ51_RS13290 Protein ID WP_003413167.1
Coordinates 2862886..2863143 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ51_RS13260 2857487..2858692 - 1206 WP_003413027.1 chorismate synthase -
FPJ51_RS13265 2859411..2860622 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ51_RS13270 2860749..2861408 + 660 WP_003902296.1 hypothetical protein -
FPJ51_RS13275 2861405..2862067 + 663 WP_003905878.1 hypothetical protein -
FPJ51_RS13280 2862064..2862341 + 278 Protein_2621 type II toxin-antitoxin system VapB family antitoxin -
FPJ51_RS13285 2862434..2862847 + 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ51_RS13290 2862886..2863143 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ51_RS13295 2863140..2863517 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ51_RS13300 2863533..2863907 - 375 WP_003413177.1 hypothetical protein -
FPJ51_RS13305 2864007..2864402 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ51_RS13310 2864399..2864644 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ51_RS13315 2865055..2865474 - 420 WP_003413190.1 A24 family peptidase -
FPJ51_RS13320 2865486..2866295 - 810 WP_003413193.1 shikimate dehydrogenase -
FPJ51_RS13325 2866292..2867545 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ51_RS13330 2867538..2868050 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-122)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T133401 WP_003413164.1 NZ_CP041856:2862434-2862847 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T133401 NZ_CP041856:2862434-2862847 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT133401 WP_003413167.1 NZ_CP041856:2862886-2863143 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT133401 NZ_CP041856:2862886-2863143 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ26


Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References