Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3804323..3804852 Replicon chromosome
Accession NZ_CP041853
Organism Mycobacterium tuberculosis strain 1-0107P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPJ55_RS17705 Protein ID WP_003417760.1
Coordinates 3804595..3804852 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPJ55_RS17700 Protein ID WP_003417757.1
Coordinates 3804323..3804598 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ55_RS17680 3801121..3802558 - 1438 Protein_3492 FAD-binding oxidoreductase -
FPJ55_RS17685 3802661..3803050 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPJ55_RS17690 3803064..3803357 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPJ55_RS17695 3803354..3804199 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPJ55_RS17700 3804323..3804598 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPJ55_RS17705 3804595..3804852 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPJ55_RS17710 3804894..3806084 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPJ55_RS17715 3806201..3806568 + 368 Protein_3499 FHA domain-containing protein -
FPJ55_RS17720 3806565..3807116 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPJ55_RS17725 3807123..3807704 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPJ55_RS17730 3807685..3808053 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPJ55_RS17735 3808031..3808423 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T133235 WP_003417760.1 NZ_CP041853:3804595-3804852 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T133235 NZ_CP041853:3804595-3804852 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT133235 WP_003417757.1 NZ_CP041853:3804323-3804598 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT133235 NZ_CP041853:3804323-3804598 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCGGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References